Antimicrobial Efficacy of Cefoperazone-Salbactam Plus Tigecycline versus Cefoperazone-Salbactam Against Respiratory Pathogens and Their Effect on Laboratory Indices

Sundas Shaukat; Zona Irfan; Haseeba Arif; Sidra Sadiq; Shehnaz Bakhtiar; Muhammad Ismail

doi:10.51253/pafmj.v73i3.10546

Authors

Sundas Shaukat Department of Pathology, Rehman Medical Institute, Peshawar Pakistan
Zona Irfan Department of Pathology, Fazaia Ruth PFAU Medical College, Karachi Pakistan
Haseeba Arif Department of Pathology, Rehman Medical Institute, Peshawar Pakistan
Sidra Sadiq Department of Pathology, Rehman Medical Institute, Peshawar Pakistan
Shehnaz Bakhtiar Department of Pathology, Khyber Institute of Child Health and Bashir Bilour Memorial Children Hospital, Peshawar Pakistan
Muhammad Ismail Department of Surgery, Combined Military Hospital, Risalpur/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v73i3.10546

Keywords:

Cefoperazone, Infections, Respiratory, Sulbactam, Tigecycline

Abstract

Objective: To compare the antimicrobial efficacy of cefoperazone plus tigecycline versus cefoperzone and their effect on
biochemical indices.

Study Design: Quasi-experimental study.

Place and Duration of Study: Department of Pathology, Rehman Medical Institute, Peshawar Pakistan, Nov 2022 to May 2023.

Methodology: Patients of either gender with age >20 years having intensive care unit stay of >72 hours having clinical and radiological evidence of hospital acquired respiratory infection were included in the trial. A non-randomized convenience sampling technique was employed. Group CT patients received a combination of cefoperazone-sulbactam plus tigecycline intravenously while Group C participants received only cefoperazone-salbactam. Demographics, inflammatory markers,pathogens, treatment effectivity were recorded.

Results: Mean age of participants in Group CT was 57.59±6.08 years as compared to 56.37±6.87 years in Group C. Pseudomonas aeruginosa was the most common pathogen identified in 30(23.8%) patients. CRP, WBC’s and PCT was significantly reduced after antibiotic treatment in both groups with a p-value of <0.01 and significant decrease in the serum levels of these markers was observed in Group CT as compared to Group C with a p-value of <0.05. Overall, the treatment effectivity was observed in 57(90.5%) participants in Group CT as compared to 46(73%) in Group C.

Conclusion: Cefoperazone-salbactam plus tigecycline offers superior antimicrobial activity as compared to cefoperazonesulbactam in patients with hospital acquired respiratory tract infections.