Urinary Tract Infections in Children with Lower Abdominal Pain

Authors

  • Abdullah Akram Department of Paediatrics, Combined Military Hospital, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
  • Waseem Ahmad Department of Paediatrics, Combined Military Hospital, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
  • Farooq Ikram Department of Paediatrics, Combined Military Hospital, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
  • Zunaira Zulfiqar Department of Paediatrics, Combined Military Hospital, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
  • Babar Ali Department of Paediatrics, Combined Military Hospital, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
  • Manal Latif Department of Paediatrics, Combined Military Hospital, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v76i1.10380

Keywords:

Children, Dysuria, Lower abdominal pain, Urinary tract infection

Abstract

Objective: To determine the association between different factors and the development of urinary tract infections in children presenting with lower abdominal pain.

Study Design: Case-control study.

Place and Duration of Study: Department of Paediatrics, Combined Military Hospital, Rawalpindi, Pakistan Aug 2022 to March 2023.

Methodology: This study was conducted on 198 paediatric patients. All patients underwent urine culture for establishing the diagnosis of a UTI and a positive culture was defined as >105 CFU/mL of a single bacterial pathogen. Patients with a positive urine culture were grouped into cases while with negative urine culture were used as controls.

Results: The mean age of our study sample was 9.61±3.62 years. Male gender (OR: 0.44 [95% Cl 0.24 – 2.57]) was associated with a lower risk of developing UTIs while obesity (OR: 4.27 [95% Cl 1.83 – 9.95]), family history of recurrent urinary tract infections (OR: 3.68 [95% Cl 1.40 – 9.67]), renal scarring (OR: 4.13 [95% Cl 0.45 – 37.59]), urinary tract anatomical abnormalities (OR: 6.06 [95% Cl 1.31 – 28.11]), low daily fluid intake (OR: 7.19 [95% Cl 3.01 – 17.19]) and decreased frequency of voiding per day (OR: 2.86 [95% Cl 1.24 – 6.57]) were all associated with an increased risk of urinary tract infections.

Conclusion: Identification of risk factors for the development of urinary tract infections in children presenting with isolated, non-specific lower abdominal pain, such as obesity, poor fluid intake and inadequate voiding can help the clinician to make  appropriate diagnoses.

Downloads

Download data is not yet available.

References

1. Bono MJ, Leslie SW, Reygaert WC. Urinary Tract Infection. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2022.

2. Kaufman J, Temple-Smith M, Sanci L. Urinary tract infections in children: an overview of diagnosis and management. BMJ Paediatr Open 2019; 3(1):e000487.

http://doi.org/10.1136/bmjpo-2019-000487

3. Kitaoka H, Inatomi J, Chikai H, Watanabe K, Kumagai T, Masui A, et al. Renal abscess with bacteremia caused by extended-spectrum β-lactamase-producing Escherichia coli: a case report. BMC Pediatr 2020; 20(1): 461.

http://doi.org/10.1186/s12887-020-02366-5

4. Bandari B, Sindgikar SP, Kumar SS, Vijaya MS, Shankar R. Renal scarring following urinary tract infections in children. Sudan J Paediatr 2019; 19(1): 25-30.

http://doi.org/10.24911/SJP.106-1554791193

5. Leung AK, Wong AH, Leung AA, Hon KL. Urinary Tract Infection in Children. Recent Pat Inflamm Allergy Drug Discov 2019; 13(1): 2-18.

http://doi.org/10.2174/1872213X13666181228154940

6. Boon HA, Van den Bruel A, Struyf T, Gillemot A, Bullens D, Verbakel JY. Clinical Features for the Diagnosis of Pediatric Urinary Tract Infections: Systematic Review and Meta-Analysis. Ann Fam Med 2021; 19(5): 437-446.

http://doi.org/10.1370/afm.2684

7. Tullus K, Shaikh N. Urinary tract infections in children. Lancet 2020; 395(10237): 1659-1668.

http://doi.org/10.1016/S0140-6736(20)30676-0

8. Renko M, Salo J, Ekstrand M, Pokka T, Pieviläinen O, Uhari M, et al. Meta-analysis of the Risk Factors for Urinary Tract Infection in Children. Pediatr Infect Dis J 2022; 41(10): 787-792.

http://doi.org/10.1097/INF.0000000000003628

9. Cetin N, Gencler A, Kavaz-Tufan A. Risk factors for development of urinary tract infection in children with nephrolithiasis. J Paediatr Child Health 2020; 56(1): 76-80.

http://doi.org/10.1111/jpc.14495

10. Hum S, Liu H, Shaikh N. Risk Factors for the Development of Febrile Recurrences in Children with a History of Urinary Tract Infection. J Pediatr 2022; 243(1): 152-157.

http://doi.org/10.1016/j.jpeds.2021.12.037

11. Mahyar A, Ayazi P, Gholmohammadi P, Moshiri SA, Oveisi S, Esmaeily S. The role of overweight and obesity in urinary tract infection in children. Infez Med 2016; 24(1): 38-42.

12. Fasugba O, Mitchell BG, McInnes E, Koerner J, Cheng AC, Cheng H, et al. Increased fluid intake for the prevention of urinary tract infection in adults and children in all settings: a systematic review. J Hosp Infect 2020; 104(1): 68-77.

http://doi.org/10.1016/j.jhin.2019.08.016

13. Gondim R, Azevedo R, Braga AA, Veiga ML, Barroso U Jr. Risk factors for urinary tract infection in children with urinary urgency. Int Braz J Urol 2018; 44(2): 378-383.

http://doi.org/10.1590/S1677-5538.IBJU.2017.0434

14. Gul A, Ekici O, Zengin S, Boyaci C. Has the COVID-19 Pandemic Affected Community-Acquired Urinary Tract Infections in Children? Urol J 2022; 19(5): 386-391.

http://doi.org/10.22037/uj.v19i.7227

15. Alrasheedy M, Abousada HJ, Abdulhaq MM, Alsayed RA, Alghamdi KA, Alghamdi FD, et al. Prevalence of urinary tract infection in children in the kingdom of Saudi Arabia. Arch Ital Urol Androl 2021; 93(2): 206-210.

http://doi.org/10.4081/aiua.2021.2.206

16. Doğan G, İpek H. Comparison of Primary and Recurrent Urinary Tract Infections in Children. Cureus 2020; 12(2): e7019.

http://doi.org/10.7759/cureus.7019

17. Leigh J, Rickard M, Sanger S, Petropoulos J, Braga LH, Chanchlani R et al. Antibiotic prophylaxis for prevention of urinary tract infections in the first year of life in children with vesicoureteral reflux diagnosed in the workup of antenatal hydronephrosis: a systematic review. Pediatr Nephrol 2020; 35(9): 1639-1646. http://doi.org/10.1007/s00467-020-04568-6

18. Sabih A, Leslie SW. Complicated Urinary Tract Infections. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2022.

19. Alhabeeb H, Baradwan S, Kord-Varkaneh H, Tan SC, Low TY, Alomar O, et al. Association between body mass index and urinary tract infection: a systematic review and meta-analysis of observational cohort studies. Eat Weight Disord 2021; 26(7): 2117-2125.

http://doi.org/10.1007/s40519-020-01101-4

20. Yim HE, Han KD, Kim B, Yoo KH. Impact of early-life weight status on urinary tract infections in children: a nationwide population-based study in Korea. Epidemiol Health 2021; 43: e2021005. http://doi.org/10.4178/epih.e2021005

21. Alanazi AN, Alanazi RS, Alanazi EN, Alanazi RM, Rabbani U. Prevalence of Nocturnal Enuresis Among Children and Its Association With the Mental Health of Mothers in Northern Saudi Arabia. Cureus 2022; 14(2): e22232.

http://doi.org/10.7759/cureus.22232

22. Ellison JS, Dy GW, Fu BC, Holt SK, Gore JL, Merguerian PA et al. Neonatal Circumcision and Urinary Tract Infections in Infants With Hydronephrosis. Pediatrics 2018; 142(1): e20173703.

http://doi.org/10.1542/peds.2017-3703

23. Scholes D, Hawn TR, Roberts PL, Li SS, Stapleton AE, Zhao LP, Stamm WE et al. Family history and risk of recurrent cystitis and pyelonephritis in women. J Urol 2010; 184(2): 564-569.

http://doi.org/10.1016/j.juro.2010.03.139

24. Loukogeorgakis SP, Burnand K, MacDonald A, Wessely K, De Caluwe' D, Rahman N, et al. Renal scarring is the most significant predictor of breakthrough febrile urinary tract infection in patients with simplex and duplex primary vesico-ureteral reflux. J Pediatr Urol 2020; 16(2): 189.e1-189.e7. http://doi.org/10.1016/j.jpurol.2019.11.018

Downloads

Published

28-02-2026

Issue

Section

Original Articles

How to Cite

1.
Akram A, Ahmad W, Ikram F, Zulfiqar Z, Ali B, Latif M. Urinary Tract Infections in Children with Lower Abdominal Pain. Pak Armed Forces Med J [Internet]. 2026 Feb. 28 [cited 2026 Mar. 5];76(1):83-7. Available from: https://pafmj.org/PAFMJ/article/view/10380