Thyroid Peroxidase Antibodies and Thyroid Dysfunction in Patients with Chronic Hepatitis C Treated with Conventional Interferon and Ribavirin

  • Amna Ashraf Combined Military Hospital, Lahore/National University of Medical Sciences (NUMS), Pakistan
  • Faisal Mehmood Combined Military Hospital, Lahore/National University of Medical Sciences (NUMS), Pakistan
  • Asma Asghar Combined Military Hospital, Lahore/National University of Medical Sciences (NUMS), Pakistan
  • Syed Karamat Hussain Shah Bukhari Combined Military Hospital, Lahore/National University of Medical Sciences (NUMS), Pakistan
  • Muhammad Umair Tufail Combined Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
  • Muhammad Ali Yousaf Pak Emirates Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Keywords: Chronic hepatitis C, Interferon alpha, Interferon-induced thyroid disorders, Thyroid disorder

Abstract

Objective: To determine the frequency of thyroid dysfunction among patients with chronic hepatitis C receiving Conventional Interferon and Ribavirin combination therapy and to compare the frequency of thyroid dysfunction among patients with thyroid peroxidase positive and negative antibodies among these patients.

Study Design: Cross-sectional study.

Place and Duration of Study: Gastroenterology Department of Medicine, Combined Military Hospital, Lahore Pakistan, from Jan to Jul 2017.

Methodology: Patients reporting chronic hepatitis C, fulfilling the required selection criteria, and received conventional Interferon and Ribavirin therapy were included. A thyroid Function test was performed at enrollment, week-12 and week- 24. The outcome was measured at week 24 by the end of treatment. Anti-Thyroid Peroxidase antibody level was measured at the time of enrollment.

Results: One hundred and fifty-seven patients were enrolled in the study. There was no difference in demographic data comparison. At the end of therapy, 5 (29.41%) male patients and 12 (70.59%) female patients developed TD, with the p-value of 0.019, which is statistically significant. 28 (17.83%) out of 157 patients had positive anti-TPO at baseline. The inferential analysis showed that there were significantly higher positive rates of pre-treatment anti-TPO in patients with TD (16 (94.11%) out of 17) when compared with patients with normal baseline anti-TPO (1 (5.89%) of 17), with the p-value of 0.001.

Conclusion: Pre-treatment anti-Thyroid Peroxidase antibodies and female gender are the most significant risk factors for developing Thyroid Dysfunction during Interferon and Ribavirin therapy.

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Published
2022-08-31
How to Cite
Ashraf, A., Mehmood, F., Asghar, A., Bukhari, S. K., Tufail, M., & Yousaf, M. (2022). Thyroid Peroxidase Antibodies and Thyroid Dysfunction in Patients with Chronic Hepatitis C Treated with Conventional Interferon and Ribavirin. Pakistan Armed Forces Medical Journal (PAFMJ), 72(4), 1270-73. Retrieved from https://pafmj.org/index.php/PAFMJ/article/view/9232
Section
Original Articles