Outcomes of Allogeneic Stem Cell Transplant in Chronic Myeloid Leukaemia - A Single-Centre Experience from Pakistan

Jehanzeb Rehman; Fayyaz Hussain; Qamar un Nisa Chaudhry; Syed Kamran Mehmood; Mehreen Ali Khan; Nighat Shahbaz

doi:10.51253/pafmj.v73i4.6857

Authors

Jehanzeb Rehman Department of Pathology, Armed Forces Bone Marrow Transplant Centre/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Fayyaz Hussain Department of Pathology, Armed Forces Bone Marrow Transplant Centre/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Qamar un Nisa Chaudhry Department of Pathology, Armed Forces Bone Marrow Transplant Centre/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Syed Kamran Mehmood Department of Pathology, Armed Forces Bone Marrow Transplant Centre/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Mehreen Ali Khan Department of Pathology, Armed Forces Bone Marrow Transplant Centre/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Nighat Shahbaz Department of Pathology, Armed Forces Bone Marrow Transplant Centre/National University of Medical Sciences (NUMS) Rawalpindi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v73i4.6857

Keywords:

Bone marrow transplantation, Chronic myeloid leukaemia (CML), Conditioning regimen, Survival analysis

Abstract

Objective: To determine indications and outcomes of stem cell transplant in Chronic Myeloid Leukemia in a tertiary care centre in Pakistan.

Study Design: Retrospective longitudinal study

Place and Duration of Study: Armed Forces Bone Marrow Transplant Center, Rawalpindi Pakistan, from Jan 2002 to Jan 2019.

Methodology: Retrospective analysis of all the patients who had undergone transplants for chronic myeloid leukaemia at our centre from 2002 to 2019 was done. Cases enrolled included patients of both genders and any age for whom data related to disease status and follow-up post-transplant was available. Patients with incomplete records and follow-ups were excluded from the study.

Results: Out of 73 patients, data from 53 patients was analyzed. At a median follow-up of 40 months, overall survival was 72%. Survival in patients <40 years was better (78%) compared to the >40 years (50%). Among the three conditioning regimens, Bu16Cy120 was the most commonly used (n=35, 66%) and had better overall survival (n=29, 83%) though statistical significance could not be established (p=0.172).

Conclusion: In addition to the established indications of resistance or intolerance to tyrosine kinase inhibitors for bone marrow transplant in CML, the non-availability/ affordability, young age, and lack of access to novel drugs can be included in underdeveloped countries like Pakistan.