Effectiveness of Intratympanic Dexamethasone with Lidocaine for Alleviation of Tinnitus

  • Zeeshan Ayub Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan
  • Azeema Ahmed Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan
  • Farah Afzal Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan
  • Majid Latif Combined Military Hospital Sialkot/National University of Medical Sciences (NUMS) Pakistan
  • Muhammad Sheraz Afzal Malik Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan
  • Naveed Ahmed Combined Military Hospital Sibi/National University of Medical Sciences (NUMS) Pakistan
Keywords: Dexamethasone, Intratympanic, Tinnitus

Abstract

Objective: To determine the effectiveness of Intratympanic Dexamethasone with Lidocaine in control of idiopathic tinnitus.

Study Design: Randomized control trial (Clinical Trials. gov Identifier: NCT04798391).

Place and Duration of Study: ENT Department, PAF Hospital, Sargodha Pakistan, from Apr 2017 to Jul 2019.

Methodology: 264 consenting patients with idiopathic unilateral tinnitus presenting at ENT Department PAF Hospital Sargodha were assessed for tinnitus severity using the modified tinnitus handicap inventory. The scores were recorded and subsequently administered intra-tympanicaly 2.0ml (milli-liter) of Dexamethasone and Lidocaine (1.5 ml Dexamethasone ± 0.5 ml 1% Lidocaine). The dose was repeated twice at weekly intervals. All the patients were reassessed on the modified tinnitus handicap inventory two weeks after the third Intra-tympanic administration, with patients divided into responsive and noresponsive groups depending on ten points or more improvement in tinnitus score.

Results: Mean modified tinnitus handicap inventory score pre-therapy was 29.6 ± 5.68, and post-therapy was 17.1 ± 7.45. Independent-sample T-test applied showed a p-value of <0.001.

Conclusion: Intratympanic Dexamethasone with lidocaine has a definitively positive outcome on tinnitus improvement.

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Published
2022-04-30
How to Cite
Ayub, Z., Ahmed, A., Afzal, F., Latif, M., Malik, M. S., & Ahmed, N. (2022). Effectiveness of Intratympanic Dexamethasone with Lidocaine for Alleviation of Tinnitus. PAFMJ, 72(2), 444-47. https://doi.org/10.51253/pafmj.v72i2.6471
Section
Original Articles

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