ASSOCIATION OF STEROID RECEPTOR EXPRESSION WITH THE CLINICAL AND HISTOLOGICAL FINDINGS IN PATIENTS WITH ENDOMETRIAL CANCER

Steroid Receptor Expression in Endometrial Cancer

  • Aisha Shahid Jinnah Postgraduate Medical Center, Karachi Pakistan
  • Ghulam Haider Jinnah Postgraduate Medical Center, Karachi Pakistan
  • Paras Memon Jinnah Postgraduate Medical Center, Karachi Pakistan
  • Shumyla Beg Jinnah Postgraduate Medical Center, Karachi Pakistan
  • Mehwish Shahzadi Aga Khan University, Karachi Pakistan
  • Kiran Abbas Aga Khan University, Karachi Pakistan
Keywords: ER expression, Endometrial Carcinoma, PR expression, Endometrioid cancer, Estrogen, Progesterone

Abstract

Objective: To determine the association of estrogen and progesterone receptor expression with the clinical and histological findings of endometrial cancer.

Study Design: Prospective observational study.

Place and Duration of Study: Jinnah Postgraduate Medical Centre, Karachi between Sep 2017 to Oct 2019.

Methodology: A total of 130 patients were diagnosed with endometrial carcinoma. Data from patient files were collected regarding tumour histology, grade, stage, tumour receptor expression, and the clinical characteristics: parity, menopausal status. The receptor expression profile was documented for each patient. Data were analyzed using SPSS version 25. The association between ER/PR expression categories and clinical/histological features were explored using the chi-square test.

Results: The estrogen and progesterone receptor expressions were significantly associated with low-grade (Grade I and II) tumours and with Stage I and Stage II endometrial carcinoma with p<0.001. About 34 (34.7%) cases of endometrioid histology were negative for both estrogen and progesterone receptors. The ER and PR negativity was strongly associated with Grade III endometrial cancer (p=0.003). The majority of the stage IV cancers were negative for both the ER and PR receptors with a p<0.001.

Conclusion: Estrogen and progesterone positivity was associated with endometrioid adenocarcinoma, well-differentiated, and less advanced stage of endometrial cancer at the time of diagnosis.

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Published
2021-10-31
How to Cite
Shahid, A., Haider, G., Memon, P., Beg, S., Shahzadi, M., & Abbas, K. (2021). ASSOCIATION OF STEROID RECEPTOR EXPRESSION WITH THE CLINICAL AND HISTOLOGICAL FINDINGS IN PATIENTS WITH ENDOMETRIAL CANCER. PAFMJ, 71(5), 1875-79. https://doi.org/10.51253/pafmj.v71i5.5802
Section
Original Articles