DETERMINATION OF DIAGNOSTIC ACCURACY OF BIOCHEMICAL PARAMETERS (CRP, LDH & FERRITIN) IN THE DIAGNOSIS OF COVID-19 IN SUSPECTED COVID CASES

Diagnostic Accuracy of Biochemical Parameters in COVID

  • Tayyaba Ashiq Combined Military Hospital Lahore/National University of Medical Sciences (NUMS) Pakistan
  • Abdus Sattar Combined Military Hospital Lahore Medical College, Lahore/National University of Medical Sciences (NUMS) Pakistan
  • Nasir Uddin Combined Military Hospital Lahore/National University of Medical Sciences (NUMS) Pakistan
  • Qamar Bashir Combined Military Hospital Lahore/National University of Medical Sciences (NUMS) Pakistan
  • Sajida Shaheen Combined Military Hospital Peshawar/National University of Medical Sciences (NUMS) Pakistan
  • Aamir Ijaz Bahria International Hospital, Rawalpindi Pakistan
Keywords: C-Reactive protein, COVID-19, Diagnostic accuracy, Ferritin, Lactate dehydrogenase, Reverse transcriptase polymerase chain reaction

Abstract

Objective: To determine the diagnostic accuracy of the Lactate Dehydrogenase, C-Reactive Protein and Ferritin in suspected patients of COVID-19.

Study Design: Cross-sectional validation study.

Place and Duration of Study: Pathology department of Combined Military Hospital Lahore in the month of May 2020.

Methodology: We included 101 adult (>18 years) symptomatic suspected COVID-19 patients of both genders. Children, pregnant women and asymptomatic patients were excluded from study. Age, gender and results of Reverse Transcriptase Polymerase Chain Reaction, Lactate Dehydrogenase, C-Reactive Protein, ferritin were recorded.

Results: Lactate Dehydrodenase had highest sensitivity (75%) with positive predictive value of 71.6% and diagnostic accuracy of 65.3% among three biochemical parameters studied. Receiver Operator Characteristic curve was studied. Area under curve of Lactate Dehydrogenase (AUC=0.65) and Ferritin (AUC=0.59) reflected their ability to prognosticate the presence of COVID19 disease. However, C-Reactive Protein (AUC=0.42) appeared to be a poor predictor of the disease.

Conclusion: Raised serum Lactate Dehydrogenase (>490 U/L) and Ferritin (>152 ng/L) levels can be used to predict the Reverse Transcriptase Polymerase Chain Reaction positivity for COVID-19 in the population of suspected patients of COVID19. However, C-Reactive Protein is a poor predictor of COVID-19.

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Published
2021-10-31
How to Cite
Ashiq, T., Sattar, A., Uddin, N., Bashir, Q., Shaheen, S., & Ijaz, A. (2021). DETERMINATION OF DIAGNOSTIC ACCURACY OF BIOCHEMICAL PARAMETERS (CRP, LDH & FERRITIN) IN THE DIAGNOSIS OF COVID-19 IN SUSPECTED COVID CASES. PAFMJ, 71(5), 1722-26. https://doi.org/10.51253/pafmj.v71i5.5749
Section
Original Articles

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