Comparison of Dexmedetomidine Plus Bupivacaine Versus Bupivacaine Alone for Spinal Anesthesia in Patients Undergoing Abdominal Hysterectomy

Mirza Sijeel Ahmad; Syed Aftab Haider; Ahmad Adnan; Atqua Sultan; Muhammad Saleem Saleemi; Umer Khan

doi:10.51253/pafmj.v72i6.4349

Authors

Mirza Sijeel Ahmad Combined Military Hospital, Multan/National University of Medical Sciences (NUMS) Pakistan
Syed Aftab Haider Nishtar Medical University, Multan Pakistan
Ahmad Adnan Combined Military Hospital, Sargodha/National University of Medical Sciences (NUMS) Pakistan
Atqua Sultan Children Complex, Multan Pakistan
Muhammad Saleem Saleemi Multan Institute of Kidney Diseases, Multan Pakistan
Umer Khan Combined Military Hospital, Lahore/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v72i6.4349

Keywords:

Analgesia, Dexmedetomidine, Spinal Anesthesia

Abstract

Objective: To determine the peri-operative analgesic efficacy and quality of block by adding Dexmedetomidine as an adjuvant to Bupivacaine for spinal anaesthesia in patients undergoing abdominal hysterectomy.

Study Design: Comparative cross-sectional Study.

Place and Duration of Study: Anesthesia Department, Nishtar Hospital, Multan Pakistan, Jan to Jun 2019.
Methodology: A total of 100 women aged 30-65 years, who were planned for abdominal hysterectomy due to benign causes, and having ASA) status I-II were included. The patients were divided into two equal groups. In Group-B, 12.5mg of 0.5% hyperbaric diluted in 3ml normal saline was administered for induction of spinal anaesthesia. In contrast, in Group-B+D, 10µg Dexmedetomidine and 12.5mg 0.5% hyperbaric Bupivacaine diluted in 3ml normal saline were given. Time of sensory and motor block onset, total duration of the block, and analgesia were noted.

Results: The mean time of sensory and motor onset was significantly lower in the Group-B+D. The total duration of sensory block was 181.6±31.6 minutes in Group-B versus 345.2±23.5 minutes in Group-B+D (p-value <0.001). The total duration of the motor block was 142.9±8.6mins in Group-B versus 314.2±8.9mins in Group-B+D (p-value <0.001). Total analgesia duration was 129.4±8.3mins in Group- B versus 263.8±13.7mins in Group-B+D (p-value <0.001). A total of 2.54±0.35mg of rescue analgesia were required in Group- B versus 1.42±0.51mg in Group-B+D (p-value <0.001).

Conclusion: The use of Dexmedetomidine as an adjuvant to Bupivacaine for spinal anaesthesia shortens the onset and prolongs the duration of sensory and motor block and the total duration of analgesia.