CORRELATION OF GLYCOSYLATED HEMOGLOBIN AND MEAN PLATELET VOLUME IN PATIENTS WITH TYPE II DIABETES MELLITUS
Objective: To determine the correlation between glycosylated hemoglobin (HBA1c) and mean platelet volume (MPV) among the patients suffering from type II diabetes mellitus.
Study Design: Correlational study.
Place and Duration of Study: Pak Emirates Military Hospital Rawalpindi, from Jun 2018 to Dec 2018.
Methodology: A total of two hundred patients with type II diabetes mellitus reporting for the routine follow-up were recruited. They were divided into two groups on the basis of HBA1c levels. Group A had patients with HBA1c level <7% and group B had patients with HBA1c levels >7%. Mean platelet volume and routine socio-demographic factors were measured and compared in both the groups.
Results: Mean duration of diabetes among the patients was 4.28 ± 5.128 years. A total of 163 (81.5%) patients were using the oral hypoglycemic while 37 (18.5%) were on the insulin. Mean platelet volume of patients in group A was 8.16 ± 0.39 while mean platelet volume of patients in group B was 9.34 ± 0.81. Strong correlation of mean platelet volume and glycosylated hemoglobin among the patients in this study (p-value <0.001). Long duration of illness also significantly different among two groups upon application of regression analysis.
Conclusion: This study showed a strong link between glycemic control i.e. glycosylated hemoglobin levels and mean platelet volume among the patients suffering from type II diabetes patients. Patients with poorly controlled DM and high levels of glycosylated hemoglobin should be routinely screened for this erythrocyte index in order to early recognize and prevent the vascular complications.