TO EVUALATE THE AMELIORATIVE ROLE OF VITAMIN E ON NEPHROTOXICITY INDUCED BY VANCOMYCIN IN RABBITS

  • Shabana Ali Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Mahwish Qaisrani Foundation University of Medical College, Islamabad Pakistan
  • Kulsoom Farhat Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Akbar Waheed Islamic International Medical College, Rawalpindi Pakistan
  • Muhamm Faisal Afridi CMH Multan Institute of Medical Sciences, Multan/National University of Medical Sciences (NUMS) Pakistan
  • Muhammad Wasiullah Khan Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Keywords: Antioxidants, Vitamin E, Vancomycin Induced, Nephrotoxicity

Abstract

Objective: To analyze the ameliorative effects of vitamin E on vancomycin-induced nephrotoxicity in rabbits.

Study Design: Laboratory based experimental study.

Place and Duration of Study: National Institute of Health, Islamabad and Department of Pharmacology and Therapeutics, Army Medical College, Rawalpindi, from Jul to Aug 2017.

Methodology: Study included seventy adult, male and female, rabbits weighing 1-2 kg. Group A served as a control group (n=10), group B (n=30) received vancomycin, 200mg/kg I/p dissolved in normal saline twice a day for seven days while group C (n=30) received oral vitamin E, 500mg/kg 5 days prior to vancomycin administration and for seven days after 200mg/kgI/p vancomycin administration. On the eighth day animals were sacrificed. Blood samples were drawn on day 0 and day 8. Estimation of kidney damage was assessed via serum urea, creatinine, sodium and potassium levels. Kidneys were assessed for histopathological examination.

Results: Vitamin E administration was buoyant in alleviating marked nephrotoxicity imposed by vancomycin (group B) by significantly decreasing serum urea (p<0.001), creatinine, (p<0.001), serum sodium (p<0.001) and serum potassium levels (p<0.001). Improvement in the renal morphology was also witnessed in group C.

Conclusion: Vitamin E successfully ameliorated the nephrotoxicity induced by vancomycin administration. This implicates the therapeutic importance of vitamin E as a nephroprotective agent.

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Published
2020-02-29
How to Cite
Ali, S., Qaisrani, M., Farhat, K., Waheed, A., Afridi, M., & Khan, M. (2020). TO EVUALATE THE AMELIORATIVE ROLE OF VITAMIN E ON NEPHROTOXICITY INDUCED BY VANCOMYCIN IN RABBITS. Pakistan Armed Forces Medical Journal, 70(1), 169-73. Retrieved from https://pafmj.org/index.php/PAFMJ/article/view/3957
Section
Original Articles