HEMATOLOGICAL DISORDERS OF PROPYLTHIOURACIL IN THYROID PATIENTS AT TERTIARY CARE HOSPITAL OF HYDERABAD

Propylthiouracil in Thyroid

  • Uzma Naz Shaikh University of Sindh, Jamshoro Pakistan
  • Muhammad Ali Ghoto University of Sindh, Jamshoro Pakistan
  • Abdullah Dayo University of Sindh, Jamshoro Pakistan
  • Mudassar Iqbal Arain University of Sindh, Jamshoro Pakistan
  • Jibran Khan University of Sindh, Jamshoro Pakistan
Keywords: Agranulocytosis, Anemia, Hyperthyroid, Propylthiouracil, Thrombocytopenia

Abstract

Objective: To find out the frequency of anemia, agranulocytosis and thrombocytopenia in hyperthyroid patients after the use of propylthiouracil.

Study Design: Cross sectional study.

Place and Duration of Study: Out Door Patients Department and Pathology Laboratory in Liaquat University Medical & Health Sciences, Hospital Hyderabad/Jamshoro, from May 2016 to Apr 2017.

Methodology: Two hundred cases, comprising of adult patients were categorized into five groups, age group 15-30 years 79 (39.5%) patients presenting the highest out of total, age group 31-45 years 68 (34%) patients, age group 46-60 years 36 (18%), age group 61-75 years 14 (7%) patients, age group >75 years 3 (1.5) patients. Complete blood count was analyzed on Sysmex Kx21 and thyroid profiles were analyzed on Elecysis 2010 from the Pathology Department. SPSS version 22 was used for data analysis.

Result: Out of total patients, 32 (16%) were males and 168 (84%) were females with mean age of 37.44 ± 14.82 years. Majority of patients 68 (34%) were anemic, while 4 (2%) had agranulocytosis and 11 (5.5%) had thrombocytopenia. Headache was reported in 111 (55.5%), exophthalmos in 106 (53%), sore throat in 172 (86%), fever in 136 (68%) and weight loss in 95 (47.5%) patients.

Conclusion: Propylthiouracil causes defective hematopoiesis in hyperthyroid patients because propylthiouracil has adverse suppressive effects on bone marrow.

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Published
2021-10-31
How to Cite
Shaikh, U., Ghoto, M., Dayo, A., Arain, M., & Khan, J. (2021). HEMATOLOGICAL DISORDERS OF PROPYLTHIOURACIL IN THYROID PATIENTS AT TERTIARY CARE HOSPITAL OF HYDERABAD. PAFMJ, 71(5), 1787-90. https://doi.org/10.51253/pafmj.v71i5.3682
Section
Original Articles