HEMATOLOGICAL DISORDERS OF PROPYLTHIOURACIL IN THYROID PATIENTS AT TERTIARY CARE HOSPITAL OF HYDERABAD: Propylthiouracil in Thyroid

Uzma Naz Shaikh; Muhammad Ali Ghoto; Abdullah Dayo; Mudassar Iqbal Arain; Jibran Khan

doi:10.51253/pafmj.v71i5.3682

Authors

Uzma Naz Shaikh University of Sindh, Jamshoro Pakistan
Muhammad Ali Ghoto University of Sindh, Jamshoro Pakistan
Abdullah Dayo University of Sindh, Jamshoro Pakistan
Mudassar Iqbal Arain University of Sindh, Jamshoro Pakistan
Jibran Khan University of Sindh, Jamshoro Pakistan

DOI:

https://doi.org/10.51253/pafmj.v71i5.3682

Keywords:

Agranulocytosis, Anemia, Hyperthyroid, Propylthiouracil, Thrombocytopenia

Abstract

Objective: To find out the frequency of anemia, agranulocytosis and thrombocytopenia in hyperthyroid patients after the use of propylthiouracil.

Study Design: Cross sectional study.

Place and Duration of Study: Out Door Patients Department and Pathology Laboratory in Liaquat University Medical & Health Sciences, Hospital Hyderabad/Jamshoro, from May 2016 to Apr 2017.

Methodology: Two hundred cases, comprising of adult patients were categorized into five groups, age group 15-30 years 79 (39.5%) patients presenting the highest out of total, age group 31-45 years 68 (34%) patients, age group 46-60 years 36 (18%), age group 61-75 years 14 (7%) patients, age group >75 years 3 (1.5) patients. Complete blood count was analyzed on Sysmex Kx21 and thyroid profiles were analyzed on Elecysis 2010 from the Pathology Department. SPSS version 22 was used for data analysis.

Result: Out of total patients, 32 (16%) were males and 168 (84%) were females with mean age of 37.44 ± 14.82 years. Majority of patients 68 (34%) were anemic, while 4 (2%) had agranulocytosis and 11 (5.5%) had thrombocytopenia. Headache was reported in 111 (55.5%), exophthalmos in 106 (53%), sore throat in 172 (86%), fever in 136 (68%) and weight loss in 95 (47.5%) patients.

Conclusion: Propylthiouracil causes defective hematopoiesis in hyperthyroid patients because propylthiouracil has adverse suppressive effects on bone marrow.