Clinical Spectrum and Drug Sensitivity Pattern in Multi Drug-Resistant Typhoid Fever

Warda Afzal; Ameena Saba; Syed Taqi Hasan Zaidi; Hamid Jamal Siddiqui; Muhammad Tahir

doi:10.51253/pafmj.v72i5.3594

Authors

Warda Afzal Karachi Institute of Medical Sciences, Karachi/National University of Medical Sciences (NUMS) Pakistan
Ameena Saba Karachi Institute of Medical Sciences, Karachi/National University of Medical Sciences (NUMS) Pakistan
Syed Taqi Hasan Zaidi Karachi Institute of Medical Sciences, Karachi/National University of Medical Sciences (NUMS) Pakistan
Hamid Jamal Siddiqui Karachi Institute of Medical Sciences, Karachi/National University of Medical Sciences (NUMS) Pakistan
Muhammad Tahir Karachi Institute of Medical Sciences, Karachi/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v72i5.3594

Keywords:

Clinical presentation, Complications, Drug susceptibility pattern, Multi drugs resistant typhoid fever

Abstract

Objectives: To study the clinical presentation, complications and drug sensitivity patterns of multi drugs- resistant enteric fever.

Study Design: Prospective longitudinal study.

Place and duration of study: Combined Military Hospital, Malir Cantt Karachi Pakistan, from Mar to Oct 2019.

Methodology: A hundred cases of multi-drug resistant enteric fever were enrolled. Their demographic data, clinical and laboratory features and drug sensitivity pattern was recorded.

Results: Out of 100 cases, 67 were within 5 to 11 years of age. Twenty-one patients presented with loose motion and splenomegaly each. Seventy cases had a fever of 1 to 2-weeks duration. Complications were seen in 42 cases, out of which hepatitis was most commonly observed (in 27 cases). Ciprofloxacin and Ceftriaxone sensitivity were found to be only 3% and 9%, respectively. Sensitivity to Azithromycin was 95%, while all cases were sensitive to Meropenem and Imipenem.

Conclusion: Very high frequency of extensively drug-resistant typhoid fever was found. Most cases of enteric fever had a fever as the only presenting feature. Typhidot test has very low sensitivity.