TO DETERMINE THE EFFECT OF GENDER, ADVANCED AGE, LONGER DURATION OF ILLNESS AND HIGHER GLYCOSYLATED HEMOGLOBIN LEVELS ON MEAN PLATELET VOLUME (MPV) IN PATIENTS OF TYPE 2 DIABETES MELLITUS

Abstract

Objective: To determine the effect of gender, advanced age, longer duration of illness and higher glycosylated
hemoglobin levels on mean platelet volume in patients of type 2 diabetes mellitus.

Study Design: Descriptive cross-sectional study.

Place and Duration of Study: Combined Military Hospital Kohat, from Jul 2017 to Aug 2018.

Methodology: In this study 248 patients with type 2 diabetes were evaluated as per inclusion/exclusion criteria.
Data from all patients was collected which included age, gender, duration of disease, symptoms & signs of target organ damage, Fasting Blood Glucose at presentation, HbA1c levels and complete blood count including mean Platelet Volume. Patients were then divided into different categories according to their gender, age, duration of illness and HbA1c levels. Mean mean platelet volume for each category was calculated and compared using student t-test. Data was analyzed using SPSS-21 and means for each group were compared.

Results: Sample size (n) was 248, 140 (57%) patients were male and 108 (43%) were female with mean mean
platelet volume of 11.51 ± 0.80fL and 11.66 ± 0.78fL respectively. Age wise stratification showed 45 patients (17%) below 50 years of age, 85 patients (37%) between 50 and 59 years, 80 patients (32%) between 60 and 69 years and 38 patients (14%) aged 70 years and more. Mean mean platelet volume for these age groups was 10.76 ± 0.61fL, 11.36 ± 0.68fL, 12.03 ± 0.60fL and 12.07 ± 0.58 fL respectively...........
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