ASSOCIATION OF HUMAN CHORIONIC GONADOTROPHIN WITH PREGNANCY INDUCED HYPERTENSION

beta HCG and pregnancy induced hypertension

  • Nayab Afzal Chatha Combined Military Hospital (CMH) Lahore Medical College, Lahore/National University of Medical Sciences (NUMS) Pakistan
  • Humaira Osman Jaffery Combined Military Hospital (CMH) Lahore Medical College, Lahore/National University of Medical Sciences (NUMS) Pakistan
  • Saima Qamar Combined Military Hospital (CMH) Lahore Medical College, Lahore/National University of Medical Sciences (NUMS) Pakistan
  • Nilofar Mustafa Combined Military Hospital (CMH) Lahore Medical College, Lahore/National University of Medical Sciences (NUMS) Pakistan
  • Rizwana Kamran Combined Military Hospital (CMH) Lahore Medical College, Lahore/National University of Medical Sciences (NUMS) Pakistan
  • Viqar Ashraf Combined Military Hospital (CMH) Lahore Medical College, Lahore/National University of Medical Sciences (NUMS) Pakistan
Keywords: β HCG, Positive predictive value, Pregnancy induced hypertension, Beta human chorionic gonadotropin (β-HCG)

Abstract

Objective: To determine the positive predictive value of beta Human Chorionic Gonadotrophin in early second
trimester for predicting pregnancy induced hypertension.

Study Design: Cross-sectional study.

Place and Duration of Study: Department of Obstetrics and Gynaecology Combined Military Hospital, Lahore,
from Jun 2017 to Nov 2017.

Methodology: A total of 214 female pregnant patients met the criteria for inclusion in this study. Patients with
beta human chorionic gonadotrophin (βHcg) levels ≥2 MoM were followed at 22, 26, 30 and 34 weeks of gestation. Blood pressure was monitored. Pregnancy induced hypertension (PIH) was labelled after 20 weeks (as per dating scan) of gestation in patients who did not have proteinuria (≥300 mg 24 hour urine sample) and had a systolic blood pressure ≥140 mmHg and/or a diastolic blood pressure ≥90 mmHg (blood pressure readings taken at two separate points in time four hours apart).

Results: Patients ranged between 18-35 years of age, with the mean age being 27.3 ± 4.3 years. Mean gestational age was observed to be 15.6 ± 1.8 weeks. Mean BMI was 23.8 ± 3.2 kg/m2. Out of 214 patients, 30 patients (14%) had beta human chorionic gonadotrophin level >2 MoM. Out of these 30 patients, 25 patients (83.3%) developed PIH. There were 100 primigravida (46.7%) and 114 multigravidas (53.3%). Beta human chorionic gonadotrophin in predicting pregnancy induced hypertension showed sensi-tivity of 96.1%, a specificity of 97.3%, with a PPV83.3%, a NPV 99.4% and diagnostic accuracy of 97.2%.

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Author Biography

Viqar Ashraf, Combined Military Hospital (CMH) Lahore Medical College, Lahore/National University of Medical Sciences (NUMS) Pakistan

 

 

Published
2020-12-15
How to Cite
Chatha, N., Jaffery, H., Qamar, S., Mustafa, N., Kamran, R., & Ashraf, V. (2020). ASSOCIATION OF HUMAN CHORIONIC GONADOTROPHIN WITH PREGNANCY INDUCED HYPERTENSION. Pakistan Armed Forces Medical Journal, 70(6), 1712-16. https://doi.org/10.51253/pafmj.v70i6.3452
Section
Original Articles