SERUM URIC ACID LEVEL IN PATIENTS WITH IMPAIRED GLUCOSE TOLERANCE AS COMPARED TO SUBJECTS WITH NORMAL GLUCOSE TOLERANCE

  • Muhammad Zubair Combined Military Hospital Lahore/National University of Medical Sciences (NUMS) Pakistan
  • Majida Farooq Combined Military Hospital Lahore/National University of Medical Sciences (NUMS) Pakistan
  • Muhammad Rafi Butt Combined Military Hospital Lahore/National University of Medical Sciences (NUMS) Pakistan
  • Muhammad Farooq Combined Military Hospital Lahore/National University of Medical Sciences (NUMS) Pakistan
  • Sajida Shaheen Combined Military Hospital Lahore/National University of Medical Sciences (NUMS) Pakistan
  • Sahar Rabbani Combined Military Hospital Lahore/National University of Medical Sciences (NUMS) Pakistan
Keywords: Diabetes mellitus (DM), Impaired fasting glucose, (IFG), Impaired glucose tolerance (IGT), Normal glucose tolerance (NGT), Oral glucose tolerance test (OGTT), Serum uric acid level (SUA)

Abstract

Objective: To determine serum uric acid level in patients with impaired glucose tolerance as compared to subjects with normal glucose tolerance.

Study Design: Case control study.

Place and Duration of Study: Department of Chemical Pathology and Endocrinology, CMH Lahore, from Jun 2016 to Nov 2016.

Methodology: Upon the referral from outdoor clinicians, approx. 300 patients were included in the study. Oral glucose tolerance test was carried out with 75 g glucose load in patients with impaired fasting glucose. Serum uric acid level was determined in both cases (impaired glucose tolerance) and control (normal glucose tolerance) groups. Serum uric acid and glucose level were performed on fully automated chemistry analyzer Selectra XL ensuring Internal and External quality Control procedures. Data was entered and analyzed on SPSS 21.

Results: Hyperuricemia was present in 84 (56%) patients who had impaired glucose tolerance. Analysis of association between cases and control groups with hyperuricemia and non hyperuricemia was done which gave p-value of <0.001 with odds ratio of 7.4.

Conclusion: Significant proportion of patients with impaired glucose tolerance had hyperuricemia in comparison to patients with normal glucose tolerance. So hyperuricemia should be considered a red flag in these patients and should alert the clinician to strive to utilize a global risk reduction program in a team effort to reduce the complications secondary to high serum uric acid level in prediabetes.

Downloads

Download data is not yet available.
Published
2019-10-23
How to Cite
Zubair, M., Farooq, M., Butt, M., Farooq, M., Shaheen, S., & Rabbani, S. (2019). SERUM URIC ACID LEVEL IN PATIENTS WITH IMPAIRED GLUCOSE TOLERANCE AS COMPARED TO SUBJECTS WITH NORMAL GLUCOSE TOLERANCE. PAFMJ, 69(5), 949-53. Retrieved from https://pafmj.org/index.php/PAFMJ/article/view/3393
Section
Original Articles

Most read articles by the same author(s)