SERUM URIC ACID LEVEL IN PATIENTS WITH IMPAIRED GLUCOSE TOLERANCE AS COMPARED TO SUBJECTS WITH NORMAL GLUCOSE TOLERANCE

Abstract

Objective: To determine serum uric acid level in patients with impaired glucose tolerance as compared to subjects with normal glucose tolerance.

Study Design: Case control study.

Place and Duration of Study: Department of Chemical Pathology and Endocrinology, CMH Lahore, from Jun 2016 to Nov 2016.

Methodology: Upon the referral from outdoor clinicians, approx. 300 patients were included in the study. Oral glucose tolerance test was carried out with 75 g glucose load in patients with impaired fasting glucose. Serum uric acid level was determined in both cases (impaired glucose tolerance) and control (normal glucose tolerance) groups. Serum uric acid and glucose level were performed on fully automated chemistry analyzer Selectra XL ensuring Internal and External quality Control procedures. Data was entered and analyzed on SPSS 21.

Results: Hyperuricemia was present in 84 (56%) patients who had impaired glucose tolerance. Analysis of association between cases and control groups with hyperuricemia and non hyperuricemia was done which gave p-value of <0.001 with odds ratio of 7.4.

Conclusion: Significant proportion of patients with impaired glucose tolerance had hyperuricemia in comparison to patients with normal glucose tolerance. So hyperuricemia should be considered a red flag in these patients and should alert the clinician to strive to utilize a global risk reduction program in a team effort to reduce the complications secondary to high serum uric acid level in prediabetes.