EFFECT OF LEVODOPA ON PERSONALITY DISTURRBANCES AND DYSEXECUTIVE SYMPTOMS IN PATIENTS WITH IDIOPATHIC PARKINSON’S DISEASE
To assess effects of levodopa (L-dopa) on personality disturbances and dysexecutive symptoms in patients with idiopathic Parkinson’s disease (PD).
Study Design: Prospective test-retest design.
Place and Duration of Study: Bahawal Victoria Hospital and Civil Hospital, Bahawalpur, Pakistan during June 2016 to June 2017.
Material and Methods:
Informants of sixty patients with idiopathic PD rated changes in personality on lowa scale of personality change and dysexecutive symptoms on dysexecutive questionnaire after three months of L-dopa treatment. Informants and clinical psychologist who collected data from informants were both blind to the objective of the study.
Personality disturbances and dysexecutive functioning (dysexecutive symptoms, inhibition, social regulation) were significantly reduced post L-dopa treatment.
L-dopa is an effective treatment for bringing positive personality and cognition related changes in patients with idiopathic PD.