NEONATAL SEPSIS IN A TERTIARY CARE HOSPITAL: BACTERIOLOGICAL PROFILE AND ITS ANTIBICROBIAL SENSITIVITY
Keywords:Antimicrobial sensitivity, Bacteriological profile, Multi drug resistance, Neonatal sepsis
To study the spectrum and antimicrobial sensitivity of bacterial pathogens causing neonatal sepsis, in neonatal intensive care unit (NICU) of Pak Emirates Military Hospital, Rawalpindi.
Study Design: Prospective cross sectional study.
Place and Duration of Study: This was a prospective cross sectional study, conducted at NICU of Military Hospital, Rawalpindi, from Jul 2017 to Dec 2017.
Material and Methods:
All neonates admitted to our department who underwent evaluation for sepsis, from Jul 2017 to Dec 2017.
Out of 2,480 admitted neonates, 733 were suspected with sepsis, making an incidence of suspected neonatal sepsis to be 29.5%. 421 (57.4%) babies were suspected with early onset sepsis (EOS) and 312 (42.6%) with late onset sepsis (LOS). Majority of the babies (70.3%) were preterm. In 281 (11.3%) neonates, blood culture came out to be positive. 73/281 neonates with culture proven sepsis died making a mortality rate of 25.9%. Gram negative bacilli were most predominant among isolated bacteria. Most of the organisms showed resistance to the first line antibiotics.
Sepsis has a high mortality rate in neonates admitted to our department. Gram negative organisms are the most common cause. Most of the isolated organisms are resistant to empirical antibiotics.