Comparative Analysis of Human Cystatin C Levels in Migraine without Aura and Healthy Controls

Authors

  • Mariyam Khan Department of Physiology, Nishtar Medical University, Multan Pakistan
  • Maham Tahir Department of Physiology, Islam Medical and Dental College, Sialkot Pakistan
  • Sunia Hameed Department of Radiology, Mukhtiar A Sheikh Hospital, Multan Pakistan
  • Muhammad Umar Ali Khan Department of Histopathology, Bakhtawar Amin Hospital, Multan Pakistan
  • Mehwish Qamar Department of Physiology, Islam Medical and Dental College, Sialkot Pakistan
  • Mamoona Shafiq Department of Physiology, Islam Medical and Dental College, Sialkot Pakistan

DOI:

https://doi.org/10.51253/pafmj.v73i4.10867

Keywords:

Cystatin C, Migraine, Protective role, Oxidative stress

Abstract

Objective: To compare the levels of human cystatin c (novel biomarker) as well as the association of other parameters in
migraine patients without aura and healthy controls.

Study Design: Cross-sectional, comparative study.

Place and Duration of Study: The research was conducted at IMBB Physiology Department, University of Lahore, Lahore
Pakistan, from May 2021 to Jun 2022.

Methodology: After taking history, a detailed clinical examination was conducted of participants in both cases and controls of
the study. A proforma was filled and a non-probability convenience sampling technique was used. The blood samples were
drawn, centrifuged to isolate serum and analyzed concentration of serum cystatin C levels were measured by using enzyme
linked immunosorbent assay (ELISA). SPSS version 22 was used for statistical analysis. Mann-Whitney U test was used to
determine the median IQR values of both groups and p-value<0.05 was considered significant.

Results: Among cases 19(47.5%) were male and 21(52.5%) were female. Mean age of cases and controls was 25.57±5.93 and
26.15±7.19 years. The most frequent occupation among cases and controls was student, doctors, nurses and house wives.
Among cases only 3(7.5%) patients were currently smokers while among controls 3(7.5%) were currently smokers. Among
cases body mass index of 11(27.5%) patients were 30 and 4(10%) participants in controls had body mass index as 30. The most
frequent symptom was photophobia followed by nausea, phonophobia, vomiting and atypical features. All these features
were significantly higher

Conclusion: Study concluded that patients with migraine without aura have elevated levels of cystatin C in their

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Published

28-07-2023

Issue

Section

Original Articles

How to Cite

1.
Mariyam Khan, Maham Tahir, Sunia Hameed, Muhammad Umar Ali Khan, Mehwish Qamar, Mamoona Shafiq. Comparative Analysis of Human Cystatin C Levels in Migraine without Aura and Healthy Controls. Pak Armed Forces Med J [Internet]. 2023 Jul. 28 [cited 2024 Jul. 25];73(4):1195-9. Available from: https://pafmj.org/PAFMJ/article/view/10867