Comparison of Serum Lipid Profile in Cirrhotic Versus Non-Cirrhotic Patients with Viral Hepatitis

Mehar Rehman; Tariq Bashir Tareen; Muhammad Umair Ijaz  Malik; Muhammad Uzair Ijaz  Malik

doi:10.51253/pafmj.v74i6.9984

Authors

Mehar Rehman Department of Medicine, PAC Hospital Kamra Pakistan
Tariq Bashir Tareen Department of Medicine, Combined Military Hospital Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
Muhammad Umair Ijaz Malik Department of Medicine, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Muhammad Uzair Ijaz Malik Department of Medicine, PAC Hospital Kamra Pakistan

DOI:

https://doi.org/10.51253/pafmj.v74i6.9984

Keywords:

Cirrhosis, Cholesterol, HDL, LDL, Triglycerides, Viral Hepatitis.

Abstract

Objective: To evaluate the association of lipoprotein cholesterol levels in cirrhotic versus non-cirrhotic patients with viral hepatitis.

Study Design: Analytical cross-sectional.

Place and Duration of Study: Department of General Medicine, Pakistan Aeronautical Complex Hospital, Kamra Pakistan, from Feb to Aug 2021.

Methodology: Our study included patients presenting to medical OPD with diagnosed chronic viral hepatitis, belonging to either gender and aged between 35 to 75 years. We collected data on a data collection tool regarding basic demographics (age, gender, weight, and etiology of viral hepatitis) and presence of cirrhosis amongst the chronic hepatitis patients was documented. We categorized patients into cirrhotic and non-cirrhotic groups where mean serum lipid levels were noted for comparison.

Results: Out of total 100 patients, mean age of the patients was 56.01±8.46 years. The mean serum cholesterol, LDL (low-density lipoprotein), HDL (high-density lipoprotein), and triglyceride levels were 143.78±26.34 mg/dL, 88.73±17.89 mg/dL, 34.94±7.87 mg/dL, and 100.32±19.18 mg/dL, respectively. A significant difference in serum cholesterol (p-value=0.0002), LDL (p-value=0.0006), HDL (p-value=0.004) and triglyceride level (p-value=0.004) was noted between cirrhotic and non-cirrhotic patients.

Conclusion: A significant difference of serum cholesterol, LDL, HDL, and triglyceride level was noted in between cirrhotic and non-cirrhotic patients.

Downloads

Download data is not yet available.

References

Fierro NA, Aldaco KG, Valadez RT, Lopez EM, Roman S, Panduro A. Immunologic, metabolic, and genetic factors in hepatitis C virus infection. World J Gastroenterol 2014; 20(13): 3443-3456.

https://doi.org/10.3748/wjg.v20.i13.3443

Hajarizadeh B, Grebely J, Dore GJ. Epidemiology and natural history of HCV infection. Nat Rev Gastroenterol Hepatol 2013; 10: 553-562. https://doi.org/10.1038/nrgastro.2013.107

Ott JJ, Stevens GA, Groeger J, Wiersma ST. Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity. Vaccine 2012; 30: 2212-2219. https://doi.org/10.1016/j.vaccine.2011.12.116

Wait S, Kell E, Hamid S, Muljono DH, Sollano J, Mohamed R, et al. Hepatitis B and hepatitis C in southeast and southern Asia: challenges for governments. Lancet Gastroenterol Hepatol 2016; 1(3): 248-255. https://doi.org/10.1016/S2468-1253(16)30030-2

Bassendine MF, Sheridan DA, Bridge SH, Felmlee DJ, Neely RDG. Lipids and HCV. Semin Immunopathol 2013; 35: 87-100. https://doi.org/10.1007/s00281-012-0349-4

Zhang J, Ling N, Lei Y, Peng M, Hu P, Chen M. Multifaceted interaction between hepatitis B virus infection and lipid metabolism in hepatocytes: a potential target of antiviral therapy for chronic hepatitis B. Front Microbiol 2021; 12: 636897. https://doi.org/10.3389/fmicb.2021.636897

Popescu CI, Dubuisson J. Role of lipid metabolism in hepatitis C virus assembly and entry. Biol Cell 2010; 102: 63-74.

https://doi.org/10.1042/BC20090075

Felmlee DJ, Hafirassou ML, Lefevre M, Baumert TF, Schuster C. Hepatitis C virus, cholesterol and lipoproteins: impact for the viral life cycle and pathogenesis of liver disease. Viruses 2013; 5: 1292-1324. https://doi.org/10.3390/v5051292

Ghadir MR, Riahin AA, Havaspour A, Nooranipour M, Habibinejad AA. The relationship between lipid profile and severity of liver damage in cirrhotic patients. Hepat Mon 2010; 10: 285-288.

Muhammed HP, Jayaraj K. Correlation of lipid profile in patients with severity of liver disease: a cross-sectional study in a tertiary care hospital. Int J Res Med Sci 2016; 5:326. https://doi.org/10.18203/2320-6012.ijrms20195521

Subhan F, Khan I, Arif R, Khan A, Khan A. Serum lipid profile as an indicator of the severity of liver damage in cirrhotic patients. Rawal Med J 2012; 37(4): 387-389.

Janicko M, Veselíny E, Lesko D, Jarcuska P. Serum cholesterol is a significant and independent mortality predictor in liver cirrhosis patients. Ann Hepatol 2013; 12: 581-587.

https://doi.org/10.1016/S1665-2681(19)31470-6.

Shahid M, Hassan R, Farhan A, Nouman S, Rehman HM, Safdar J, et al. National prevalence rate of hepatitis B and C in Pakistan and its risk factors. J Public Health 2020; 28(6): 751-764. https://doi.org/10.1007/s10389-019-01146-1

Abbasi A, Bhutto AR, Butt N, Lal K, Munir SM. Serum cholesterol: could it be a sixth parameter of Child-Pugh scoring system in cirrhotics due to viral hepatitis. J Coll Physicians Surg Pak 2012; 22(8): 484-487.

Haq MI, Salim A, Malik K, Dilshad A, Amin J, Butt AK, et al. Correlation of Child-Pugh class of cirrhosis and lipid profile. Proceeding SZPGMI 2016; 30(1): 19-23.

Kumar W, Harisha E. Assessment of lipid profile changes with respect to severity of liver dysfunction in cirrhosis of liver. Indian J Appl Basic Med Res 2015; 4(2): 56-63.

Lao XQ, Thompson A, McHutchison JG, McCarthy JJ. Sex and age differences in lipid response to chronic infection with the hepatitis C virus in the United States National Health and Nutrition Examination Surveys. J Viral Hepat 2011; 18(8): 571-579. https://doi.org/10.1111/j.1365-2893.2010.01340.x

Hu JH, Chen MY, Yeh CT, Lin HS, Lin MS, Huang TJ, et al. Sexual dimorphic metabolic alterations in hepatitis C virus-infected patients: a community-based study in a hepatitis B/hepatitis C virus hyperendemic area. Medicine (Baltimore) 2016; 95(18): e3530.

https://doi.org/10.1097/MD.0000000000003530

Corey KE, Kane E, Munroe C, Barlow LL, Zheng H, Chung RT. Hepatitis C virus infection and its clearance alter circulating lipids: implications for long-term follow-up. Hepatology 2009; 50: 1030-1037. https://doi.org/10.1002/hep.23102

Habib A, Mihas AA, Abou-Assi SG, Williams LM, Gavis E, Pandak WM. High-density lipoprotein cholesterol as an indicator of liver function and prognosis in noncholestatic cirrhotics. Clin Gastroenterol Hepatol 2005; 3(3): 286-291.

https://doi.org/10.1016/S1542-3565(04)00647-5