Comparative Efficacy of 25% Trichloroacetic Acid Peel Versus 30% Salicylic Acid Peel in Mild to Moderate Acne Vulgaris

Kiran Gul; Bushra  Muzaffar; Muhammad Adeel  Siddiqui; Majid  Hussain; Sara  Ilyas; Huma  Farid

doi:10.51253/pafmj.v75i5.9910

Authors

Kiran Gul Department of Dermatology, Combined Military Hospital Abbotabad/National University of Medical Sciences (NUMS) Pakistan
Bushra Muzaffar Department of Dermatology, Combined Military Hospital Abbotabad/National University of Medical Sciences (NUMS) Pakistan
Muhammad Adeel Siddiqui Department of Dermatology, Combined Military Hospital Abbotabad/National University of Medical Sciences (NUMS) Pakistan
Majid Hussain Department of Dermatology, Combined Military Hospital Jhelum/National University of Medical Sciences (NUMS) Pakistan
Sara Ilyas Department of Dermatology, Combined Military Hospital Abbotabad/National University of Medical Sciences (NUMS) Pakistan
Huma Farid Department of Dermatology, Combined Military Hospital Abbotabad/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v75i5.9910

Keywords:

Acne Vulgaris, Michaelson Acne Score, Salicylic Acid, Trichloroacetic Acid

Abstract

Objective: To compare the efficacy of 25% trichloroacetic acid peel (TCA) versus 30% salicylic acid peel (SA) in mild to moderate acne vulgaris.

Study Design: Randomized Control Trial (ClinicalTrials.gov: NCT05712837).

Place and Duration of Study: Department of Dermatology, Combined Military Hospital, Abbottabad Pakistan, from Jun to Nov 2022.

Methodology: Sixty patients with mild and moderate facial acne vulgaris (i.e, comedones, papules and pustules) diagnosed by consultant dermatologist on clinical presentation were included in this study. After randomization, patients were divided into two groups. Group-A was managed with 25% Trichloroacetic Acid (TCA) peel, while Group-B was managed with 30% Salicylic acid (SA) peel. Clinical evaluation was done and recorded initially at the start of therapy and then at every fourth week for twelve weeks. Efficacy was compared in both groups at the end of twelve weeks.

Results: 30% SA peel was more efficacious in achieving good MAS count (64.57±1.176) at the end of 12-weeks as compared to 25% TCA peel (54.30±3.52) (p-value <0.001).

Conclusion: This randomized controlled trial showed that 30% SA peel was more efficacious in treating mild-to-moderate acne vulgaris of the face compared to 25% TCA peel.

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