Efficacy of 5% Minoxidil Versus Platelet Rich Plasma in Treatment of Alopecia Areata
DOI:
https://doi.org/10.51253/pafmj.v74i6.9722Keywords:
Alopecia, Efficacy, Minoxidil, Platelet Rich Plasma.Abstract
Objective: To determine the efficacy of 5% Minoxidil versus Platelet Rich Plasma in treatment of alopecia areata.
Study Design: Quasi experimental study.
Place and Duration of Study: Department of Dermatology, Sheikh Zayed Hospital, Lahore, Pakistan, from Apr to Sep 2022.
Methodology: A total of 122 patients with alopecia areata, aged between 18-40 years and belonging to both genders, were enrolled after taking written, informed consent and were randomly and equally divided between two groups, of which, group A, received 5% Minoxidil, while group B, received intralesional Platelet Rich Plasma. Efficacy was assessed over 12 weeks in terms of improvement in Severity of Alopecia Tool (SALT) score.
Results: The mean age of the patients in group A was 25.1±6.1 years while in group B, it was 26.3±5.0 years. The mean SALT score at baseline was 74.3±7.8 versus 73.0±6.8 (p=0.311), while the mean SALT score at 12 weeks was 37.3±9.6 versus 33.6±8.7 (p=0.029) respectively. Comparison of efficacy of Minoxidil versus Platelet Rich Plasma revealed that Minoxidil was effective in 33 patients (54.1%), whereas, Platelet Rich Plasma was effective in 46 patients (75.4%), with this difference being statistically significant (p-value ≤0.05).
Conclusion: Platelet Rich Plasma was significantly more effective than Minoxidil in the treatment of patients presenting with alopecia areata.
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References
Roohaninasab M, Goodarzi A, Ghassemi M, Sadeghzadeh‐Bazargan A, Behrangi E, Najar Nobari N, et al. Systematic review of platelet‐rich plasma in treating alopecia: focusing on efficacy, safety, and therapeutic durability. Dermatol Ther 2021; 34(2): e14768.
https://doi.org/10.1111/dth.14768
Barbulescu CC, Goldstein NB, Roop DR, Norris DA, Birlea SA. Harnessing the power of regenerative therapy for vitiligo and alopecia areata. J Invest Dermatol 2020; 140(1): 29–37.
https://doi.org/10.1016/j.jid.2019.07.643
Anitua E, Pino A, Jaén P, Navarro MR. Platelet-rich plasma for the management of hair loss: better alone or in combination? J Cosmet Dermatol 2019; 18(2): 483–486.
https://doi.org/10.1111/jocd.12727
Almohanna HM, Ahmed AA, Griggs JW, Tosti A. Platelet-rich plasma in the treatment of alopecia areata: a review. J Investig Dermatol Symp Proc 2020; 20(1): 45–49.
https://doi.org/10.1016/j.jisp.2019.11.006
Pototschnig H, Madl MT. Successful treatment of alopecia areata barbae with platelet-rich plasma. Cureus 2020; 12(4): e7500.
https://doi.org/10.7759/cureus.7500
Sterkens A, Lambert J, Bervoets A. Alopecia areata: a review on diagnosis, immunological etiopathogenesis and treatment options. Clin Exp Med 2021; 21(2): 215–230.
https://doi.org/10.1007/s10238-020-00636-y
Zheng C, Tosti A. Alopecia areata: new treatment options including Janus kinase inhibitors. Dermatol Clin 2021; 39(3): 407–415.
https://doi.org/10.1016/j.det.2021.02.009
Fukumoto T, Fukumoto R, Magno E, Oka M, Nishigori C, Horita N, et al. Treatments for alopecia areata: a systematic review and network meta‐analysis. Dermatol Ther 2021; 34(3): e14916.
https://doi.org/10.1111/dth.14916
English RS, Ruiz S, DoAmaral P. Microneedling and its use in hair loss disorders: a systematic review. Dermatol Ther 2021; 34(1): e14618. https://doi.org/10.1111/dth.14618
Alves R, Grimalt R. Platelet-rich plasma and its use for cicatricial and non-cicatricial alopecias: a narrative review. Dermatol Ther 2020; 10(4): 623–633.
https://doi.org/10.1007/s13555-020-00417-3
Gentile P, Garcovich S. Systematic review of platelet-rich plasma use in androgenetic alopecia compared with Minoxidil®, Finasteride®, and adult stem cell-based therapy. Int J Mol Sci 2020; 21(8): 2702. https://doi.org/10.3390/ijms21082702
Khademi F, Tehranchinia Z, Abdollahimajd F, Younespour S, Kazemi‐Bajestani SM, Taheri K. The effect of platelet-rich plasma on hair regrowth in patients with alopecia areata totalis: a clinical pilot study. Dermatol Ther 2019; 32(4): e12989.
https://doi.org/10.1111/dth.12989
Wyrwich KW, Kitchen H, Knight S, Aldhouse NV, Macey J, Nunes FP, et al. Development of the scalp hair assessment PRO™ measure for alopecia areata. Br J Dermatol 2020; 183(6): 1065–1072. https://doi.org/10.1111/bjd.18958
Hesseler MJ, Shyam N. Platelet-rich plasma and its utilities in alopecia: a systematic review. Dermatol Surg 2020; 46(1): 93–102.
https://doi.org/10.1097/DSS.0000000000002104
Kowe PA, Madke B, Bansod SH. Oral Minoxidil in trichology: a review. Indian J Drugs Dermatol 2022; 8(1): 1–6.
Pourang A, Mesinkovska NA. New and emerging therapies for alopecia areata. Drugs 2020; 80(7): 635–646.
https://doi.org/10.1007/s40265-020-01299-6
El Taieb MA, Ibrahim H, Nada EA, Seif Al‐Din M. Platelets rich plasma versus Minoxidil 5% in treatment of alopecia areata: a trichoscopic evaluation. Dermatol Ther 2017; 30(1): e12437.
https://doi.org/10.1111/dth.12437
Shumez H, Prasad PV, Kaviarasan PK, Deepika R. Intralesional platelet-rich plasma vs intralesional triamcinolone in the treatment of alopecia areata: a comparative study. Int J Med Res Health Sci 2015; 4(1): 118–122.
Cervelli V, Garcovich S, Bielli A, Cervelli G, Curcio BC, Scioli MG, et al. The effect of autologous activated platelet-rich plasma (AA-PRP) injection on pattern hair loss: clinical and histomorphometric evaluation. Biomed Res Int 2014; 2014: 760709. https://doi.org/10.1155/2014/760709
Zhou C, Li X, Wang C, Zhang J. Alopecia areata: an update on etiopathogenesis, diagnosis, and management. Clin Rev Allergy Immunol 2021; 61(3): 403–423.
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Copyright (c) 2024 Saman Iqbal Goraya, Safoora Aamir, Beenish Jabeen, Beenish Rahat, Tassmia Afzal, Riffat Naseem
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