Role of Dexmedetomidine Infusion on Renal Dysfunction in Patients Undergoing Coronary Artery Bypass Graft Surgery: A Randomized Control Trial

Authors

  • Haris Tariq Chohan National Institute of Cardiovascular Diseases, Karachi Pakistan
  • Amin M. Khuwaja National Institute of Cardiovascular Diseases, Karachi Pakistan, *Army Cardiac Centre, Lahore Pakistan
  • Sajjad Ahmed National Institute of Cardiovascular Diseases, Karachi Pakistan
  • Aftab Ahmed National Institute of Cardiovascular Diseases, Karachi Pakistan
  • Maaida Muzaffar National Institute of Cardiovascular Diseases, Karachi Pakistan
  • Rashad Siddiqui Army Cardiac Centre, Lahore Pakistan

DOI:

https://doi.org/10.51253/pafmj.v72iSUPPL-3.9561

Keywords:

Cardiac surgery-associated acute kidney injury, Dexmetedomidine, Serum creatinine

Abstract

Objective: To find out the effect of Dexmedetomidine infusion on renal function in patients undergoing Coronary Artery Bypass Graft (CABG) surgery.

Study Design: Randomized control trial (RCT- NCT05375188).

Place and Duration of Study: The research was conducted in the Department of Anesthesia, National Institute of Cardiovascular Diseases Karachi Pakistan, from Jun to Sep 2021.

Methodology: 60 patients were allocated randomly into two groups. In Group-D, Dexmetedomidine was given as an infusion of 0.4 μg/kg/h from induction of anesthesia for 24 hours. In Group-C, patients were receiving an equal volume of normal saline. The primary outcome of the study was Serum Creatinine (mg/dl) which was measured 24 hours before the surgery as baseline and then 24 hours and 48 hours after surgery.

Results: In Group-C Serum Creatinine was found to be 0.96 +/- 0.21mg/dl at baseline, 1.02 +/- 0.35 mg/dl after 24 hours and 1.38 +/- 0.47 mg/dl after 48 hours of surgery. In Group-D Serum Creatinine was found to be 0.76 +/- 0.12 mg/dl at baseline,0.85 +/- 0.17 mg/dl after 24 hours and 0.82+/- 0.24 mg/dl after 48 hours of surgery. p-value was found to be <0.001 after 48hours of surgery.

Conclusion: Dexmetedomidine infusion significantly reduced incidence of acute kidney injury in patients undergoing
coronary artery bypass graft surgery.

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Published

22-11-2022

Issue

Section

Original Articles

How to Cite

1.
Chohan HT, Khuwaja AM, Ahmed S, Ahmed A, Muzaffar M, Siddiqui R. Role of Dexmedetomidine Infusion on Renal Dysfunction in Patients Undergoing Coronary Artery Bypass Graft Surgery: A Randomized Control Trial. Pak Armed Forces Med J [Internet]. 2022 Nov. 22 [cited 2024 Dec. 25];72(SUPPL-3):S580-84. Available from: https://pafmj.org/PAFMJ/article/view/9561