Comparison of 5% Potassium Hydroxide with 10% Potassium Hydroxide Solution in Treatment of Molluscum Contagiosum
DOI:
https://doi.org/10.51253/pafmj.v75i1.9509Keywords:
Drug Efficacy, Molluscum Contagiosum (MC), Potassium Hydroxide (KOH)Abstract
Objective: To compare the efficacy of 5% potassium hydroxide against 10% potassium hydroxide solution in the management of molluscum contagiosum.
Study Design: Randomized Controlled Trial (ClinicalTrials.gov:NCT05634460).
Place and Duration of Study: Department of Dermatology, Combined Military Hospital, Abbottabad Pakistan, from Mar to Aug 2022.
Methodology: We enrolled 60 patients, aged between 2-14 years, by using non-probability consecutive sampling. All patients having molluscum contagiosum were randomly assigned to one of two groups, where Group-A received 5% KOH, and Group-B received 10% KOH solution, which was applied to patient’s lesions, by their parents, once daily, for two weeks, or until inflammatory manifestations. All patients were monitored for side effects after Week 2, 4, 8, and 12. Efficacy classification was based on complete remission (>90%), partial remission (60-90%), and insignificant improvement (<60%). Demographic information and frequency percentages were calculated for qualitative variables. The chi-square test was applied to establish statistical significance, with p-value ≤0.05 considered significant.
Results: In Group-B, after Week 12, 19(63.3%) patients had complete remission while 11(36.7%) patients had partial remission (p<0.05). In Group-A, only 1(3.3%) patient had complete remission, but partial remission was observed in 22(73.3%) patients. In Group-A, erythema was noted in 17(56.7%) patients and burns in 13(43.3%) patients, but in Group-B, 30(100%) patients complained of burning and erythema, 14(46.6%) had pruritis and 12(40%) developed crusting (p<0.05).
Conclusions: In treating molluscum contagiosum, a 10% KOH solution was found to be more efficacious than a 5% KOH solution.
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References
Edwards S, Boffa MJ, Janier M. 2020 European guideline on the management of genital molluscum contagiosum. J Eur Acad Dermatol Venereol 2021; 35(1): 17–26.
https://doi.org/10.1111/jdv.16805
Bugert JJ, Alikhan A, Shwayder T. Molluscum contagiosum. Harper's Textbook of Pediatric Dermatology 2019: 579–587.
Costa HR, Guimarães EA, Tedesco AC, et al. Experimental study of the neurotoxic effects of photodynamic therapy on the spinal cord. Coluna 2019; 18: 176–180.
https://doi.org/10.1590/S1808-185120191803213472
Forbat E, Al‐Niaimi F, Ali FR. Molluscum contagiosum: review and update on management. Pediatr Dermatol 2017; 34(5): 504–515.
https://doi.org/10.1111/pde.13226
Meza-Romero R, Navarrete-Dechent C, Downey C. Molluscum contagiosum: an update and review of new perspectives in etiology, diagnosis, and treatment. Clin Cosmet Investig Dermatol 2019; 12: 373–381.
https://doi.org/10.2147/CCID.S174917
Vakharia PP, Chopra R, Silverberg NB. Efficacy and safety of topical cantharidin treatment for molluscum contagiosum and warts: a systematic review. Am J Clin Dermatol 2018; 19(6): 791–803.
https://doi.org/10.1007/s40257-018-0385-3
Phan S, Wyant C, Huynh C. Efficacy of topical treatments for molluscum contagiosum in randomized controlled trials. Clin Dermatol 2021; 39(6): 1005-1013.
https://doi.org/10.1016/j.clindermatol.2021.07.016
Heo JY, Park TH, Kim WI. The efficacy and safety of topical 10% potassium hydroxide for molluscum contagiosum: a systematic review and meta-analysis. J Dermatolog Treat 2022; 33(3): 1682–1690.
https://doi.org/10.1080/09546634.2020.1770165
Giner-Soriano M, Teixidó C, Marsal JR. Randomized placebo-controlled clinical trial on efficacy and safety of topical 10% potassium hydroxide for molluscum contagiosum treatment in children. J Dermatolog Treat 2019; 30(4): 376–380.
https://doi.org/10.1080/09546634.2018.1495685
Baloch HS, Ahmed N, Bari AU. Efficacy of 5% potassium hydroxide versus 10% potassium hydroxide solution for the treatment of molluscum contagiosum at a tertiary care hospital. Pak Armed Forces Med J 2021; 71(6): 2135–2138.
Muzaffar F, Faiz F. Randomised controlled trial for comparison of 5% potassium hydroxide with 10% potassium hydroxide solution in treatment of molluscum contagiosum: a comparative study. J Pak Assoc Dermatol 2014; 24(4): 337–341.
Can B, Topaloğlu F, Kavala M. Treatment of pediatric molluscum contagiosum with 10% potassium hydroxide solution. J Dermatolog Treat 2014; 25(3): 246–248.
https://doi.org/10.3109/09546634.2012.762678
Robinson G, Townsend S, Jahnke MN. Molluscum contagiosum: review and update on clinical presentation, diagnosis, risk, prevention, and treatment. Curr Dermatol Rep 2020; 9(1): 83–92.
https://doi.org/10.1007/s13671-020-00277-3
Romiti R, Ribeiro AP, Grinblat BM. Treatment of molluscum contagiosum with potassium hydroxide: a clinical approach in 35 children. Pediatr Dermatol 1999; 16(3): 228–231.
https://doi.org/10.1046/j.1525-1470.1999.00064.x
Uçmak D, Akkurt MZ, Kacar SD. Comparative study of 5% and 2.5% potassium hydroxide solution for molluscum contagiosum in children. Cutan Ocul Toxicol 2014; 33(1): 54–59.
https://doi.org/10.3109/15569527.2013.807231
Romiti R, Ribeiro AP, Romiti N. Evaluation of the effectiveness of 5% potassium hydroxide for the treatment of molluscum contagiosum. Pediatr Dermatol 2000; 17(6): 495.
https://doi.org/10.1046/j.1525-1470.2000.01761.x
Potassium hydroxide. Available from:
https://en.wikipedia.org/wiki/Potassium_hydroxide (Cited August 23, 2022).
Muzaffar F, Ali GN. 10% Potassium hydroxide solution vs. cryotherapy in the treatment of molluscum contagiosum: a case-control study. J Pak Assoc Dermatol 2011; 21(3): 185–189
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