Effects of Lower Limb Amputations on Bone Health of Amputees: Study from A Developing Country
DOI:
https://doi.org/10.51253/pafmj.v74i2.9391Keywords:
Bone Mineral Density, DEXA Scan, Osteoporosis, Osteopenia, Transfemoral Amputation, Transtibial Amputation, Foot Amputation, TTA, TFAAbstract
Objective: To measure the BMD in young adults with traumatic or non-traumatic lower limb amputation, using DEXA scan.
Study Design: Comparative cross sectional study
Place and Duration: Armed Forces Institute of Rehabilitation Medicine from July to December 2021.
Methodology: Adults of age ≥18 years, admitted in amputee ward of AFIRM with lower limb amputation (traumatic or non-traumatic, unilateral or bilateral, new or follow up cases) were included in the study. All patients were undergoing DEXA scan for the first time since amputation. Patients were divided into 3 groups: transtibial amputation (TTA), transfemoral amputation (TFA) and ankle/foot amputation groups. Z-scores were documented for lumbar spine (L1-L4) and neck of femur (NOF). Z-scores at NOF were documented on amputated as well as non-amputated sides.
Results: A total of 47 patients participated in the study. All were male. Mean age of patients was 30.8 ± 7.1 years (Range: 21-48 years). Majority of the patients (n=28, 59.6%) had left lower limb amputation. Out of 47 patients, TTA group comprised of 37 (78.7%) patients, TFA group comprised of 3 (6.4%) and ankle/foot group comprised of 5 (10.7 %) patients. Independent sample t-test was applied to determine the difference in Z-scores at NOF between amputated and non-amputated side in TTA group and result was statistically significant (p <0.001).
Conclusion: A significant number of lower limb amputees suffer from reduced BMD. This is the well identified risk factor for NOF / hip fractures. Health care professionals must understand the significance of identifying amputees with low BMD.
Downloads
References
Ahmad A, Ashfaq O, Akhtar N, Rana T, Gul M. Causes of lower
limb amputation in patients registered at Pakistan Institute of
Prosthetic and Orthotic Sciences Peshawar-Pakistan. Khyber
Med Univ J 2019; 11(1): 41-44.
https://doi.org/10.35845/kmuj.2019.18096
McDonald CL, Westcott-McCoy S, Weaver MR, Haagsma J,
Kartin D. Global prevalence of traumatic non-fatal limb
amputation. Prosth Orthot Int 2020; 1-12.
https://doi.org/10.1177/0309364620972258
Gill ZA, Ayaz SB, Khan AA, Ahmad N, Akhtar N, Ahmad M.
Major limb amputations among civilian population at a central
military amputee rehabilitation center. Pak Armed Forces Med J
; 66: 76-80.
Finco MG, Kim S, Ngo W, Menegaz RA. A review of
musculoskeletal adaptations in individuals following major
lower-limb amputation. J Musculoskelet Neuronal Interact 2022
; 22(2): 269-283.
Webster JB. Lower Limb Amputation Care Across the Active
Duty Military and Veteran Populations. Phys Med Rehabil Clin
N Am 2019;30(1):89-109.
https://doi.org/10.1016/j.pmr.2018.08.008
Kranioti EF, Bonicelli A, García-Donas JG. Bone-mineral density:
clinical significance, methods of quantification and forensic
applications. Res Rep Forensic Med Sci 2019 (9): 9-21.
https://doi.org/10.2147/RRFMS.S164933
Haleem S, Yousaf S, Hamid T, Nagappa S, Parker MJ.
Characteristics and outcomes of hip fractures in lower limb
amputees. Injury 2021; 52(4): 914-917.
https://doi.org/10.1016/j.injury.2020.10.017
Bemben DA, Sherk VD, Ertl WJJ, Bemben MG. Acute bone
changes after lower limb amputation resulting from traumatic
injury. Osteoporos Int 2017 ;28(7): 2177-2186.
https://doi.org/10.1007/s00198-017-4018-z
Flint JH, Wade AM, Stocker DJ, Pasquina PF, Howard RS, Potter
BK. Bone mineral density loss after combat-related lower
extremity amputation. J Orthop Trauma 2014; 28(4): 238-244.
https://doi.org/10.1097/BOT.0b013e3182a66a8a
Newhall K, Spangler E, Dzebisashvili N, Goodman DC,
Goodney P. Amputation Rates for Patients with Diabetes and
Peripheral Arterial Disease: The Effects of Race and Region. Ann
Vasc Surg 2016; 30: 292-8.e1.
https://doi.org/10.1016/j.avsg.2015.07.040
Leclercq MM, Bonidan O, Haaby E, Pierrejean C, Sengler J.
Etude de la masse osseuse par ostéodensitométrie dans une
population de 99 amputés de membre inférieur [Study of bone
mass with dual energy x-ray absorptiometry in a population of
lower limb amputees]. Ann Readapt Med Phys 2003; 46(1):
-30. https://doi.org/10.1016/s0168-6054(02)00350-1
Yazicioglu K, Tugcu I, Yilmaz B, Goktepe AS, Mohur H.
Osteoporosis: A factor on residual limb pain in traumatic transtibial amputations. Prosthet Orthot Int 2008; 32(2): 172-178.
https://doi.org/10.1080/03093640802016316.
Lewiecki EM, Gordon CM, Baim S, Leonard MB, Bishop NJ,
Bianchi ML, et al. International Society for Clinical
Densitometry 2007 Adult and Pediatric Official Positions. Bone
; 43(6): 1115-1121.
https://doi.org/10.1016/j.bone.2008.08.106
Rathore FA, Ayaz SB, Mansoor SN, Qureshi AR, Fahim M.
Demographics of Lower Limb Amputations in the Pakistan
Military: A Single Center, Three-Year Prospective Survey.
Cureus 2016; 8(4): e566. https://doi.org/10.7759/cureus.566.
Khan MT, Husain FN, Ahmed A. Hindfoot injuries due to
landmine blast accidents. Injury 2002; 33(2): 167-171.
https://doi.org/10.1016/s0020-1383(01)00092-4
Gill ZA, Ayaz SB, Tassadaq N, Matee S, Ashraf K, Rehman SU.
Problems related to prosthetic components seen in amputees of
Pakistan law enforcement agencies during prosthetic episodes.
Rawal Med J 2020; 45(3): 656-660.
Narang IC, Jape VS. Retrospective study of 14,400 civilian
disabled (new) treated over 25 years at an artificial limb centre.
Prosthet Orthot Int 1982; 6(1): 10-16.
https://doi.org/10.3109/03093648209167732
Pooja GD, Sangeeta L. Prevalence and aetiology of amputation
in Kolkata, India: A retrospective analysis. Hong Kong
Physiother J 2013; 31(1):3 6-40.
https://doi.org/10.1016/j.hkpj.2012.12.002
Soomro N, Khan M, Ahmed SI, Minhas MA. Determinants of
lower extremity amputations: an institutional experience. J Coll
Physicians Surg Pak. 2013; 23(7): 491-494.
Razzaq S, Mansoor SN, Rathore FA, Akhtar N, Yasmeen R.
Functional Outcomes Following Lower Extremity Amputation
At The Armed Forces Institute Of Rehabilitation Medicine Using
Lower Extremity Functionl Scale. Pak Armed Forces Med J 2013;
(2): 210-215.
Smith É, Comiskey C, Carroll Á, Ryall N. A study of bone
mineral density in lower limb amputees at a national prosthetics
center. J.Prosthet.Orth2011; 23(1): 14-20.