Comparison of Intravenous Tramadol vs Intravenous Morphine in Attenuation of Hemodynamic Stress response to Laryngoscopy and Endotracheal Intubation in Laparoscopic Cholecystectomy

Basit Mehmood Khan; Farrukh Ayub; Sundas Shoukat; Syed Khurram Naseer; Umer Hayat; Junaid Zafar

doi:10.51253/pafmj.v73i2.9199

Authors

Basit Mehmood Khan Combined Military Hospital, Peshawar/National University of Medical Sciences (NUMS) Pakistan
Farrukh Ayub Combined Military Hospital, Mardan/National University of Medical Sciences (NUMS) Pakistan
Sundas Shoukat Combined Military Hospital, Peshawar/National University of Medical Sciences (NUMS) Pakistan
Syed Khurram Naseer Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Umer Hayat Pakistan Air Force Hospital, Shorkot Pakistan
Junaid Zafar Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v73i2.9199

Keywords:

Tracheal intubation, Intravenous Morphine, Hemodynamic stress response

Abstract

Objective: To compare the efficacy of intravenous Tramadol and intravenous Morphine in attenuation of hemodynamic stress response to laryngoscopy and endotracheal intubation in laparoscopic cholecystectomy.

Study Design: Quasi-experimental study

Place and Duration: Department of Anesthesia, Combined Military Hospital, Mardan Pakistan, from Jun 2021 to Jun 2022.

Methodology: A total of 136 patients were involved in the research. These patients were divided via a lottery method into two groups i.e., Group-T (Tramadol) and Group-M (Morphine) with 68 patients in each group. Patients aged 20-50 years planned for laparoscopic cholecystectomy with American Society of Anesthesiologists (ASA) Grade I or Grade II were included in the study.

Results: Out of a total of 136 patients with equal distribution of 68(50%) patients in each group. Patients with ASA– I Grade from Group–T and Group-M were 52(76.5%) and 41(60.1%), respectively; however, ASA–II Grade patients were 16(23.5%) from Group–T and 27(39.7%) from Group–M. In this study, intravenous Tramadol was effective in 48(70.5%) out of 68 patients, while intravenous Morphine was effective in 60(88.24%) patients, with a p-value of 0.01.

Conclusion: This study concluded that intravenous Morphine is more effective in attenuating hemodynamic stress response to laryngoscopy and endotracheal intubation in laparoscopic cholecystectomy than intravenous Tramadol.