SAPHO (Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis); A Case of Backache in an Adolescent in Pakistan

Authors

  • Abdul Rehman Azeem Dar Department of Medicine, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Maira Aleem Department of Microbiology, National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Ali Akhtar Department of Medicine, National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Muhammad Zahid Hussain Department of Medicine, National University of Medical Sciences (NUMS) Rawalpindi

DOI:

https://doi.org/10.51253/pafmj.v73i6.9130

Keywords:

: SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis), Chronic recurrent multifocal osteoarthritis (CRMO), Chronic non-bacterial osteomyelitis (CNO)

Abstract

SAPHO (Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis) syndrome is a group of rare auto-inflammatory disorders with a
wide range of dermatological and osteoarticular manifestations. Different nomenclatures, like Chronic Recurrent Multifocal
Osteoarthritis (CRMO) and Chronic Non-Bacterial Osteomyelitis (CNO), have been used in the past for the same disease, but
SAPHO Syndrome has been the accepted terminology since 1990. An adolescent, 17 years of age, with a six-month history of inflammatory backache and fatigue, reported to a rheumatology clinic. His health assessment questionnaire- disability indexcame out to be two. Acne on physical examination raised inflammatory markers, and characteristic findings of SAPHO
syndrome on bone scan suggest the disease. The patient was treated with an excellent response to bisphosphonates. The
report highlights the importance of the evaluation of inflammatory backache in adolescents. SAPHO syndrome is an
underdiagnosed disease. Therefore, more awareness of this disease among healthcare physicians is required.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

Kishimoto M, Taniguchi Y, Tsuji S, Ishihara Y, Deshpande GA,Maeda K, et al. SAPHO syndrome and pustulotic arthro-osteitis.Mod Rheumatol 2022; 32: 665–674.https://doi.org/10.1093/mr/roab103.

Haris M, Gupta H, Haris M, Gupta H. Synovitis, Acne,Pustulosis, Hyperostosis, and Osteitis Syndrome – A Pictorial

Review. Indian J Musculoskelet Radiol 2019; 1: 41–46.http://dx.doi.org/10.25259/IJMSR_16_2019.

Figueiredo ASB, Oliveira AL, Caetano A, Moraes-Fontes MF.SAPHO: has the time come for tailored therapy? Clin Rheumatol2020; 39: 177–187. https://doi.org/10.1007/S10067-019-04675-2.

Abbasse A, Moustapha N, Mohamed DL, Hassan A, Abbasse A,Moustapha N, et al. SAPHO Syndrome: About Three Cases andReview of the Literature. Open J Internal Med 2021; 11: 109–121.https://doi.org/10.4236/ojim.2021.112009.

Kerrison C, Davidson JE, Cleary AG, Beresford MW.Pamidronate in the treatment of childhood SAPHO syndrome.

Rheumatol 2004; 43: 1246–1251.https://doi.org/10.1093/rheumatology/keh295.

Wu N, Shao Y, Huo J, Zhang Y, Cao Y, Jing H, et al. Clinicalcharacteristics of pediatric synovitis, acne, pustulosis,

hyperostosis, and osteitis (SAPHO) syndrome: the first Chinesecase series from a single center. Clin Rheumatol 2021; 40: 1487–1495. https://doi.org/10.1007/s10067-020-05393-w.

Przepiera-Bȩdzak H, Brzosko M. SAPHO syndrome:pathogenesis, clinical presentation, imaging, comorbidities andtreatment: a review. Postepy Dermatol Alergol 2021; 38: 937–942.https://doi.org/10.5114%2Fada.2020.97394.

Downloads

Published

30-12-2023

How to Cite

Dar, A. R. A., Maira Aleem, Ali Akhtar, & Muhammad Zahid Hussain. (2023). SAPHO (Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis); A Case of Backache in an Adolescent in Pakistan. Pakistan Armed Forces Medical Journal, 73(6), 1876–1878. https://doi.org/10.51253/pafmj.v73i6.9130

Issue

Section

Case Reports

Most read articles by the same author(s)