SAPHO (Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis); A Case of Backache in an Adolescent in Pakistan

Abdul Rehman Azeem Dar; Maira Aleem; Ali Akhtar; Muhammad Zahid Hussain

doi:10.51253/pafmj.v73i6.9130

Authors

Abdul Rehman Azeem Dar Department of Medicine, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Maira Aleem Department of Microbiology, National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Ali Akhtar Department of Medicine, National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Muhammad Zahid Hussain Department of Medicine, National University of Medical Sciences (NUMS) Rawalpindi

DOI:

https://doi.org/10.51253/pafmj.v73i6.9130

Keywords:

: SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis), Chronic recurrent multifocal osteoarthritis (CRMO), Chronic non-bacterial osteomyelitis (CNO)

Abstract

SAPHO (Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis) syndrome is a group of rare auto-inflammatory disorders with a
wide range of dermatological and osteoarticular manifestations. Different nomenclatures, like Chronic Recurrent Multifocal
Osteoarthritis (CRMO) and Chronic Non-Bacterial Osteomyelitis (CNO), have been used in the past for the same disease, but
SAPHO Syndrome has been the accepted terminology since 1990. An adolescent, 17 years of age, with a six-month history of inflammatory backache and fatigue, reported to a rheumatology clinic. His health assessment questionnaire- disability indexcame out to be two. Acne on physical examination raised inflammatory markers, and characteristic findings of SAPHO
syndrome on bone scan suggest the disease. The patient was treated with an excellent response to bisphosphonates. The
report highlights the importance of the evaluation of inflammatory backache in adolescents. SAPHO syndrome is an
underdiagnosed disease. Therefore, more awareness of this disease among healthcare physicians is required.

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