Clomiphene Supported Ovulation Induction in Subfertile Polycystic Ovary Syndrome Women: Role of Different Insulin Sensitizers

Shagufta Parveen; Nabila Iram; Bushra Zahid Saeed; Umairah Yaqub; Najmusaqib Khan Niazi

doi:10.51253/pafmj.v73i3.9081

Authors

Shagufta Parveen Department of Obstetrics & Gynecology, Combined Military Hospital, Khairan, Medical College, Khairan/National University of Medical Sciences (NUMS) Pakistan
Nabila Iram Department of Obstetrics & Gynecology, Prince Alexandra Hospital, Harlow United Kingdom
Bushra Zahid Saeed Department of Obstetrics & Gynecology, Prince Alexandra Hospital, Harlow United Kingdom
Umairah Yaqub Department of Obstetrics & Gynecology, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Najmusaqib Khan Niazi Combined Military Hospital, Khairan/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v73i3.9081

Keywords:

Clomiphene citrate, Insulin resistance, Metformin, Myo-inositol, Polycystic ovary syndrome

Abstract

Objective: To compare Clomiphene Citrate, ovulation induction efficacy following using insulin sensitises, Metformin versus Myo-inositol in subfertile women with polycystic ovary syndrome.

Study Design: Prospective comparative study.

Place and Duration of Study: Department of Obstetrics and Gynaecology, Combined Military Hospital, Kharian Pakistan, from Jun to Nov 2021.

Methodology: A total of 316 patients with polycystic ovary syndrome and infertility who were included in the study. Group-A was administered Metformin, whereas Group-B as given Myo-inositol. Both groups were given clomiphene citrate for ovulation induction and were followed for six months.

Results: There were 316 patients (158 in each Group). The mean age was 29.2±0.5 years, and the BMI of 23.2±1.7 Kg/m2 in both. Ovulation recorded in Group-A (Metformin) was 141(44.6%) versus Group-B (Myo-inositol), 103(32.6%). The pregnancy test was positive 33(21.1%) patients of Group-A versus 29(18.4%) of Group-B. The common complaints seen in both groups were nausea and vomiting 2(0.6%), while headache 1(0.3%) and dizziness 2(0.6%) occurred only in Group-B.

Conclusion: Clomiphene citrate with Metformin, as first-line therapy for sub-fertile women with polycystic ovary syndrome, improved ovulation and had fewer side effects than Myo-inositol.