Association of Biochemical Markers with Presence of Retinopathy Among Patients Managed with Type-II Diabetes

Syed Ali Ghawas; Muhammad Faheem; Anam Manzoor Alam; Ahsan Mehmood; Muhammad Adil; Mustajab Alam

doi:10.51253/pafmj.v75iSUPPL-6.9018

Authors

Syed Ali Ghawas Department of Medicine, Combined Military Hospital Skardu/National University of Medical Sciences (NUMS) Pakistan
Muhammad Faheem Department of Medicine, 2 mountain medical battalion
Anam Manzoor Alam Department of Gynae, Combined Military Hospital Skardu/National University of Medical Sciences (NUMS) Pakistan
Ahsan Mehmood Department of Medicine, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Muhammad Adil Department of Anesthesia, Fauji Foundation Hospital, Rawalpindi Pakistan
Mustajab Alam Department of Pathology, Combined Military Hospital Skardu/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v75iSUPPL-6.9018

Keywords:

Diabetic retinopathy; Microalbuminuria; Type II DM; uric acid

Abstract

Objective: To look for association of uric acid levels, erythrocyte sedimentation rate, LDL-cholesterol and microalbuminuria with presence of retinopathy among patients managed with Type-II Diabetes

Study Design: Comparative cross-sectional study

Place and Duration of Study: Department of Medicine, Combined Military Hospital Skardu from November 2021 to June 2022

Subjects and Methods: The sample population comprised of 120 type II diabetes patients managed either with oral hypoglycemic agents or insulin. Diabetic retinopathy was diagnosed by consultant ophthalmologist of our own hospital. Patients underwent all baseline investigations including biochemical markers included in the study. Association of uric acid levels, erythrocyte sedimentation rate, LDL-cholesterol and microalbuminuria was established with presence of diabetic retinopathy among the study participants.

Results: Out of 120 patients of type-II diabetes mellitus included in the study, 76(63.3%) were male while 44(36.7%) were female. Mean age of the patients was 44.59±6.175 years. Mean duration of type-II Diabetes Mellitus in the study participants was 4.23±4.56 years. Out of 120 patients, 75(62.5%) patients had no diabetic retinopathy while 45(37.5%) patients had retinopathy. Statistical analysis revealed that hyperuricemia and microalbuminuria had statistically significant association with presence of diabetic retinopathy in study participants (p-value<0.05).

Conclusion: Considerable number of patients with type-II diabetes mellitus had diabetic retinopathy in our data set. Patients with raised serum uric acid levels and presence of microalbuminuria were found more at risk of having diabetic retinopathy as compared to those patients who did not have these biochemical abnormalities.

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