Comparison of Quantitative and Semi-quantitative D-dimer in the Diagnosis of Deep Venous Thrombosis
DOI:
https://doi.org/10.51253/pafmj.v75iSUPPL-1.8986Keywords:
Deep venous thrombosis (DVT), D-dimer, Quantitative, Semiquantitative.Abstract
Objective: To compare sensitivity along with the specificity of quantitative and semi-quantitative D-dimer tests in patients of Deep venous thrombosis.
Study Design: Cross-sectional study.
Place and Duration of Study: Department of Haematology, Armed Forces Institute of Pathology, Rawalpindi Pakistan, from Mar 2021 to Feb 2022.
Methodology: A total of 176 patients were recruited using a nonprobability consecutive sampling technique. Patients with age <60 years and suspected of having deep venous Deep venous thrombosis were included. Patients with age >60 years and who were on anticoagulation therapy or have raised D-dimer due to other causes were excluded. The sample obtained in the trisodium citrate tube was analyzed both by semi-quantitative and quantitative methods. A value above 200ng/ml was considered positive. Sensitivity, specificity, and negative and positive predictive values were measured. Receiver Operating Characteristic was made taking Doppler ultrasound as a gold standard.
Results: In our study males 116(60%) and females 60(34%). Based on the gold standard test, and Doppler ultrasound, 24(14%), patients did not have Deep venous thrombosis while 152(86%) were diagnosed with Deep venous thrombosis. The Quantitative D-dimer test has a sensitivity of 98.7% and a specificity of 73.1%. Whereas sensitivity, specificity, positive and negative predictive value of the semiquantitative test was 92.7%, 100%, 92.1%, and 52.1% respectively. The area under the Receiver Operating Characteristic curve was 0.911 for the semiquantitative test and 0.873 for a quantitative test.
Conclusions: Semiquantitative D-dimer test has acceptable sensitivity and better specificity as compared to quantitative assay using Doppler ultrasound as a gold
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