Comparison of Hyperglycemic Effects of Antenatal Administration of Dexamethasone in Gestational Diabetes: A Study of Recommended Versus Predicted Split Doses Regimens


  • Shagufta Parveen Department of Obstetrics and Gynecology, Combined Military Hospital, Kharian Medical College Khaian/National University of Medical Sciences (NUMS) Pakistan
  • Saima Batool Department of Pediatrics, University College of Medicine & Dentistry, Lahore Pakistan
  • Saima Rafique Department of Obstetrics and Gynecology, University College of Medicine & Dentistry, Lahore Pakistan
  • Nabila Iram Department of Obstetrics and Gynecology, Prince Alexandra Hospital, Harlow England
  • Rabeya Rehman Department of Pediatrics, Sargodha Medical College, Sargodah Pakistan
  • Iffat Rafeeq Department of General Medicine, Combined Military Hospital, Kharian Medical College Kharian/National University of Medical Sciences (NUMS) Pakistan



Dexamethasone, Gestational Diabetes Mellitus, Preterm Labour, Respiratory distress


Objective: To compare three consecutive days of hyperglycemic response following antenatal Dexamethasone regimens of 12mg or 6mg in diet-controlled gestational diabetes, administered for fetal lung maturity.

Study Design: Quasi-experimental study

Place and Duration of Study: Department of Obstetrics and Gynaecology, Combined Military Hospital, Kharian Pakistan, from Oct 2020 to Mar 2021.

Methodology: Forty women who met inclusion criteria were selected and assigned to two Groups. Group-A was administered quartered 24 mg steroids 6 hours daily, and Group-B was administered halved 24mg 12 hours daily. Blood sugar levels (BSL) were recorded before and after meals, thrice a day for three consecutive days, and on proforma.

Results: Among the selected patients, the mean age was 25.5±2.9 years, and the mean gestational age (duration of pregnancy) was 30.3±2.0 weeks. Out of six blood sugar levels recorded daily for three consecutive days, the episodes of hyperglycemia in the (Group-B) 12-hourly steroid dose were found to be less significant than those in the (Group-A) split 6-hourly dose.

Conclusion: The recommended 12 mg, twice-a-day regimen of antenatal corticosteroids was better than the proposed 6mg, four times a day regimen as it caused fewer hyperglycemic episodes in gestational diabetics.


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How to Cite

Shagufta Parveen, Saima Batool, Saima Rafique, Nabila Iram, Rabeya Rehman, Iffat Rafeeq. Comparison of Hyperglycemic Effects of Antenatal Administration of Dexamethasone in Gestational Diabetes: A Study of Recommended Versus Predicted Split Doses Regimens. Pak Armed Forces Med J [Internet]. 2024 Apr. 29 [cited 2024 May 24];74(2):438-41. Available from:



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