Comparison of Pre-Mixed Human Insulin with Insulin Analog in Diabetic Control at Tertiary Care Hospital

Authors

  • Syed Fahad Ul Hassan Department of General Medicine, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Muhammad Zahid Hussain Department of General Medicine, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Ishtiaq Munir Janjua Department of General Medicine, Combined Military Hospital, Khairan/National University of Medical Sciences (NUMS) Pakistan
  • Hassan Salim Department of General Medicine, Fauji Foundation Hospital, Rawalpindi Pakistan
  • Saadia Javed Department of General Medicine, DHQ Teaching Hospital, Sargodha Pakistan
  • Muhammad Tahir Younas Department of General Medicine, Pakistan Air Force Hospital, Islamabad Pakistan

DOI:

https://doi.org/10.51253/pafmj.v74i1.8855

Keywords:

Blood glucose, Insulin analog, Mixed human insulin, Type-2 DM, Glycemic control, Glycated hemoglobin

Abstract

Objective: To compare the effect of pre-mixed human insulin with insulin analogue in diabetic control among type-2 Diabetes mellitus patients at tertiary care hospital.

Study Design: Comparative cross-sectional study.

Place and Duration of Study: Department of Medicine, Pak Emirates Military Hospital, Rawalpindi, Pakistan, from Jun 2021
to Apr 2022.

Methodology: Eleven hundred and fifty-six patients with poorly controlled type-2 diabetes on oral hypoglycemic agents
requiring insulin were recruited for the study. Patients were divided into two groups via a lottery method. Group-A received
the pre-mixed human insulin, while Group-B received the Insulin analogue advised by the consultant endocrinologist or
medical specialist according to the requirements based on recent investigations. Diabetes control was compared in both
groups at the end of twelve weeks of treatment.

Results: Out of 1156 patients with type-2 diabetes mellitus included in the study, 810(70.1%) were male, while 346(29.9%) were female. The mean duration of DM in the study participants was 3.42±4.44 years. At the end of three months, 978(84.6%) patients had good glycemic control, while 178(15.4%) patients had poor glycemic control. Statistical analysis revealed that the type of insulin used to manage these patients had no significant relationship with glycemic control in our study participants (p-value>0.05).
Conclusion: No statistically significant difference was observed in the number of patients achieving adequate glycemic control between those using pre-mixed human insulin and those using insulin analogue in our study.

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Published

28-02-2024

How to Cite

Hassan, S. F. U., Hussain, M. Z., Janjua, I. M., Salim, H., Javed, S., & Younas, M. T. (2024). Comparison of Pre-Mixed Human Insulin with Insulin Analog in Diabetic Control at Tertiary Care Hospital. Pakistan Armed Forces Medical Journal, 74(1), 67–70. https://doi.org/10.51253/pafmj.v74i1.8855

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