Comparison of Disease Severity in Established Rheumatoid Arthritis by DAS28-ESR and Clinical Disease Activity Index

Aakash Aslam; Amer Fakhr; Farhan Zaid; Syed Najaf Abbas; Jamshaid Iqbal; Hafiz Muhammad Umer

doi:10.51253/pafmj.v74i5.8775

Authors

Aakash Aslam Department of Medicine, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Amer Fakhr Department of Medicine, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Farhan Zaid Department of Medicine, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Syed Najaf Abbas Department of Medicine, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Jamshaid Iqbal Department of Medicine, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Hafiz Muhammad Umer Department of Medicine, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v74i5.8775

Keywords:

Disease scoring, Inflammatory disease, Rheumatoid arthritis.

Abstract

Objective: To compare disease severity in established rheumatoid arthritis by Disease Activity Score-28 for Rheumatoid Arthritis with Erythrocyte sedimentation rate (DAS28-ESR) and Clinical Disease Activity Index.

Study Design: Cross-sectional study.

Place and Duration of Study: Rheumatology Department, Pak Emirates Military Hospital, Rawalpindi Pakistan, from Jul 2021 to Feb 2022.

Methodology: Patients diagnosed with active Rheumatoid Arthritis were clinically evaluated in detail by consultant rheumatologist. Disease activity and severity was assessed by using DAS-28 and Clinical Disease Activity Index. Association of disease severity on DAS-28 was established with severity on Clinical Disease Activity Index and other socio-demographic factors.

Results: Mean age of the study participants was 35.81±8.45 years. In our sample, 303(75.75%) patients were female while 97(24.25%) were male. As per DAS-28 scoring, 175(43.75%) had mild, 142(35.5%) had moderate while 83(20.75%) had severe Rheumatoid Arthritis while as per Clinical Disease Activity Index scoring, 176(44%) had mild, 145(36.25%) had moderate while 79(19.75%) had severe Rheumatoid Arthritis. Disease severity on DAS-28 was strongly associated with disease severity on Clinical Disease Activity Index (p-value <0.001).

Conclusion: Severity of illness with DAS28-ESR had significant association with severity on Clinical Disease Activity Index, thus, both scales can be used interchangeably depending upon choice of clinician and availability of resources.

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