Biopsy Proven Renal Morphology Cognizance into its Four-Year Evolving Pattern; A Pakistani Perspective


  • Zain ul Abedin KRL Hospital, Islamabad Pakistan
  • Zahid Nabi KRL Hospital, Islamabad Pakistan
  • Nosheen Anjum KRL Hospital, Islamabad Pakistan
  • Fasi Hashmi Allama Iqbal Open University, Islamabad Pakistan
  • Khurram Mansoor Combined Military Hospital, Malir/ National University of Medical Sciences (NUMS) Pakistan
  • Muhammad Ishaque KRL Hospital, Islamabad Pakistan



Biopsy, Glomerulonephritis, Kidney Disease, Renal Disease


Objective: To determine the pattern of Biopsy Proven Renal Diseases (BPRD) in a single tertiary care centre in Islamabad, Pakistan.

Study Design: Cross-sectional study.

Place and Duration of Study: Department of Nephrology, KRL Hospital, Islamabad Pakistan, from Mar 2016 to Nov 2020.

Methodology: The archival records of all native renal biopsies performed in adults (>18 years) were retrospectively analyzed.The biopsies were performed according to standard indications and evaluated by light microscopy and immunofluorescence.

Results: A total of 134 renal biopsies were studied. Among these, 85(61.1 %) were males, and 49(36.5 %) were females. The mean age was 44.70±14.63 years. Primary glomerulonephritis’s were the predominant group of diseases found in 93(69.4%) cases. Membranous nephropathy (MN) was the most common lesion in 52(38.8%), followed by focal segmental Glomerulosclerosis (FSGS) in 22(16.4%) cases. Chronic tubulointerstitial nephritis (Ch. TIN) 12(9.0%) was the third most common lesion among all biopsies. Other diagnoses included lupus nephritis (LN) 10(7.5%) and IgA nephropathy (IgAN) 9(6.7%). One sample one-sided t-test was used to estimate the minimum proportion of occurrence of different biopsies in our concerned population. The estimated minimum proportion of membranous nephropathy (MN) was 0.31, with a p-value of 0.034.

Conclusion: We concluded that primary Glomerulonephritis (PGN) is the most common renal disease, and membranous nephropathy is the most common biopsy-proven Glomerulopathy in our concerned population.


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Original Articles

How to Cite

ul Abedin Z, Nabi Z, Anjum N, Hashmi F, Mansoor K, Ishaque M. Biopsy Proven Renal Morphology Cognizance into its Four-Year Evolving Pattern; A Pakistani Perspective. Pak Armed Forces Med J [Internet]. 2023 Feb. 24 [cited 2024 Jul. 23];73(1):191-94. Available from: