Comparison of Neonatal Outcome of Late Pre-Term Neonates Associated with and Without Intrauterine Growth Retardation

Authors

  • Hassnain Shahid Department of Pediatric, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Farooq Ikram Department of Pediatric, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Maryam Saleem Department of Pediatric, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Hafiz Zulqarnain Department of Pediatric, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Saeed Zaman Department of Pediatric, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Atif Naseem Abbasi Department of Pediatric, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v73i6.8605

Keywords:

Intrauterine growth retardation, Neonates, Outcome, Pre-term

Abstract

Objective: To compare the neonatal outcome of late pre-term neonates with and without intrauterine growth retardation at a nursing intensive care unit of our hospital

Study Design: Comparative cross-sectional study.

Place and Duration of Study: Pak Emirates Military Hospital ,Rawalpindi Pakistan, from Jun 2021 to Jan 2022.

Methodology: Patients were divided into two groups for comparison, late pre-term neonates with and without intrauterine
growth retardation. Intrauterine growth retardation was assessed via ultrasound examination at >29 and <34 weeks of
gestation. Neonatal outcome parameters were compared in neonates with and without intrauterine growth retardation.

Results: A total of 110 neonates were included in the final analysis. Of them, 69(62.7%) were male, while 41(37.3%) were
females. Patients were divided into two groups for the sake of comparison. Fifty-eight (52.7%) had no intrauterine growth
retardation, while 52(47.3%) had intrauterine growth retardation. Statistical analysis revealed that longer duration of
admission, hypoglycemia and hyperbilirubinemia were found statistically significantly more in late pre-term neonates who
had intrauterine growth retardation as compared to those who did not have intrauterine growth retardation (p-value<0.05).

Conclusion: Intrauterine growth retardation was a commonly observed finding among neonates who were born at late preterm. Neonates with intrauterine growth retardation were more at risk of certain complications like long stay at the neonatal intensive care unit, hypoglycemia and hyperbilirubinemia

Downloads

Download data is not yet available.

References

Al-Wassia H, Saber M. Admission of term infants to the neonatal

intensive care unit in a Saudi tertiary teaching hospital:

cumulative incidence and risk factors. Ann Saudi Med 2017;

(6): 420‐424. https://doi.org/10.5144/0256-4947.2017.420

Quddusi AI, Razzaq A, Hussain S, Hussain A. Pattern of

neonatal admission at the Children's Hospital and the Institute of

Child Health, Multan. J Ayub Med Coll Abbottabad 2012; 24(2):

‐110

Chow S, Chow R, Popovic M. A Selected Review of the Mortality

Rates of Neonatal Intensive Care Units. Front Public Health 2015;

(1): 225. https://doi.org/10.3389%2Ffpubh.2015.00225

Fisher AL, Sangkhae V, Presicce P, Chougnet CA, Jobe AH,

Kallapur SG, et al. Fetal and amniotic fluid iron homeostasis in

healthy and complicated murine, macaque, and human

pregnancy. JCI Insight 2020; 5(4): e135321.

https://doi.org/10.1172/jci.insight.135321

Salman M, Rathore H, Arif S, Ali R, Khan AA, Nasir M, et al.

Frequency of Immediate Neonatal Complications (Hypoglycemia and Neonatal Jaundice) in Late Preterm and Term

Neonates. Cureus 2021; 13(1): e12512.

Neonatal Outcome of Late Pre-Term Neonates Associated

Pak Armed Forces Med J 2023; 73(6): 1710

https://doi.org/10.7759/cureus.12512

Khowaja WH, Leghari AL, Hussain AS, Ariff S, Khan IA.

Frequency and Early Complications of Late Preterm Infants: A

Descriptive Analysis from Two Secondary-care Hospitals of

Karachi. Cureus 2019; 11(9): e5789.

https://doi.org/10.7759/cureus.5789.

Sharma D, Shastri S, Sharma P. Intrauterine Growth Restriction:

Antenatal and Postnatal Aspects. Clin Med Insights Pediatr 2016;

(3): 67-83. https://doi.org/10.4137/CMPed.S40070

Colella M, Frérot A, Novais ARB, Baud O. Neonatal and LongTerm Consequences of Fetal Growth Restriction. Curr Pediatr

Rev 2018; 14(4): 212-218.

https://doi.org/10.2174/1573396314666180712114531

Ortigosa Rocha C, Bittar RE, Zugaib M. Neonatal outcomes of

late-preterm birth associated or not with intrauterine growth

restriction. Obstet Gynecol Int 2010; 2010(1): 231842.

https://doi.org/10.1155/2010/231842

Haroon A, Ali SR, Ahmed S, Maheen H. Short-term neonatal

outcome in late preterm vs. term infants. J Coll Phys Surg Pak

; 24(1): 34-38.

Ortigosa Rocha C, Bittar RE, Zugaib M. Neonatal outcomes of

late-preterm birth associated or not with intrauterine growth

restriction. Obstet Gynecol Int 2010; 2010(3): 231842.

https://doi.org/10.1155/2010/231842

Chew LC, Verma RP. Fetal Growth Restriction. Treasure Island

(FL): StatPearls Publishing; 2021, Available at:

https://www.ncbi.nlm.nih.gov/books/NBK562268/

Karnati S, Kollikonda S, Abu-Shaweesh J. Late preterm infants -

Changing trends and continuing challenges. Int J Pediatr Adolesc

Med 2020; 7(1): 36-44.

https://doi.org/10.1016%2Fj.ijpam.2020.02.006

Karataşlı V, Kanmaz AG, İnan AH, Budak A, Beyan E. Maternal

and neonatal outcomes of adolescent pregnancy. J Gynecol

Obstet Hum Reprod 2019; 48(5): 347-350.

https://doi.org/10.1016/j.jogoh.2019.02.011

Mallick AK, Venkatnarayan K, Thapar RK, Tewari VV, Shaw SC.

Morbidity Patterns of Late Preterm Babies Born Small for

Gestation. Indian J Pediatr 2019; 86(7): 578-583.

https://doi.org/10.1007/s12098-019-02925-4

Kc A, Wrammert J, Nelin V, Ewald U, Clark R, Målqvist M, et al.

Level of mortality risk for babies born preterm or with a small

weight for gestation in a tertiary hospital of Nepal. BMC Public

Health 2015; 15(2): 877.

https://doi.org/10.1186/s12889-015-2232-1

Acmaz G, Ozdemir F, Sahin E, Sahin ME, Madendag Y, Demir

TB, et al. Adverse fetal outcomes in patients with IUGR are

related with fetal diaphragm evaluation parameters. Paediatr

Respir Rev 2021; 37(3): 48-53.

https://doi.org/10.1016/j.prrv.2020.07.005

Kreko E, Kola E, Sadikaj F, Dardha B, Tushe E. Neonatal

Morbidity in Late Preterm Infants Associated with Intrauterine

Growth Restriction. Open Access Maced J Med Sci 2019; 7(21):

-3595. https://doi.org/10.3889%2Foamjms.2019.832

Downloads

Published

30-12-2023

Issue

Section

Original Articles

How to Cite

1.
Shahid H, Ikram F, Saleem M, Zulqarnain H, Zaman S, Atif Naseem Abbasi. Comparison of Neonatal Outcome of Late Pre-Term Neonates Associated with and Without Intrauterine Growth Retardation. Pak Armed Forces Med J [Internet]. 2023 Dec. 30 [cited 2024 Dec. 26];73(6):1707-10. Available from: https://pafmj.org/PAFMJ/article/view/8605