THE EFFECT OF HYOSCINE BUTYLBROMIDE ON 1ST STAGE OF LABOUR IN TERM PREGRENCACY

Effect of Hyoscine Butylbromide in Pregnancy

Abstract

Objective: To determine the effect of hyoscoine butylbromide in shortening active phase of 1st stage of labour without adverse effects in mother and fetus.
Study Design: Randomized, double- blinded placebo controlled trail.
Place and Duration: Labour ward of PNS SHIFA hospital for duration of 06 months from 1st Jan 2008 to 30 June 2008
Patients and Method: One hundred pregnant women both primigravida and multigravida in active phase of spontaneous labour (an active phase is defined as 3 cm or more cervical dilatation with regular uterine contraction) were included in the study. Either drug or placebo was given intravenously once the women entered active labour. Progress of labour was plotted on partogram student ‘t’ test was applied for comparison of two groups.
The duration of 1st stage of labour was main outcome. Secondary outcome measures included duration of second and third stages of labour, blood loss at delivery, and apgar score in neonates between the two groups.
Result: In patient receiving hyocscine butylbromide the active phase of 1st stage of labour was 194.8 ± 87.3 mins as compared to placebo group where active phase 1st stage of labour was 282.3 ± 92.3. There was significant difference in duration of active phase 1st stage in both groups of (87.5 mins), There was no significant change in duration of second and third stage of labour, no difference in blood loss, and apgar score in both groups.
Conclusion: Hyoscine butybromide is effective significantly in reducing duration of 1st stage of labour in primigravida and multigravida with term pregnancy and it is not associated with any adverse out come in mother or neonate.