The Clinical Course of Typhoid Fever And Resistance Pattern of Salmonella Typhi In Patients Admitted To A Tertiary Care Hospital In Pakistan

Authors

  • Jamal Azfar Khan Department of Medicine, Pakistan Navy Ship Shifa Hospital Bahria University Medical & Dental College Karachi Pakistan
  • Muhammad Irfan Khattak Department of Medicine, Pakistan Navy Ship Shifa Hospital Bahria University Medical & Dental College Karachi Pakistan
  • Fazila Sikandar Department of Medicine, Pakistan Navy Ship Shifa Hospital Bahria University Medical & Dental College Karachi Pakistan
  • Muhammad Luqman Satti Department of Pathology, Pakistan Navy Ship Shifa Hospital Bahria University Medical & Dental College Karachi Pakistan
  • Kashif Razzaq Department of Medicine, Pakistan Navy Ship Shifa Hospital Bahria University Medical & Dental College Karachi Pakistan
  • Nadia Aziz Ather Department of Medicine, Pakistan Navy Ship Shifa Hospital Bahria University Medical & Dental College Karachi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v74i2.8498

Keywords:

Azithromycin, drug resistance, multiple, Meropenem, Pakistan, Salmonella typhi, typhoid fever

Abstract

Objective: To investigate and document the clinical course of typhoid fever and the sensitivity pattern of Salmonella typhi to
antibiotics among patients admitted to Pakistan Naval Ship Shifa Hospital.

Study Design: Cross-sectional study.

Place and Duration of Study: Pakistan Naval Ship Shifa Hospital, from Jul to Dec 2021.

Methodology: The patients admitted with typhoid fever to the hospital during the study period were included using
consecutive sampling. After getting informed consent, the patients’ demographic characteristics, course of the disease, blood
culture sensitivity, the treatment administered, the complications that emerged, and the length of their hospital stay were
noted.

Results: There were 77 patients with culture-proven typhoid fever admitted during the study period. The mean age was
18.6±11.84 years (range 1-55 years). The most frequent presenting complaints were fever, abdominal pain, and vomiting.
Additional symptoms included a rash, bodily aches, and weariness. Out of the 77 patients, 76(99%) were extensively drugresistant (sensitive to Meropenem and Azithromycin only). The complications noted were hepatitis, myocarditis, ascites,
pleural effusion, and shock. The mean length of stay in the hospital was 16.56+3.87 days. The typical time gap between
commencing culture-specific antibiotics and fever defervescence was 4.03±2.84 days.

Conclusion: Almost all (99%) patients admitted with typhoid fever in PNS Shifa are extensively drug-resistant and require a
relatively longer hospital stay for management.

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Published

29-04-2024

How to Cite

1.
Khan JA, Khattak MI, Sikandar F, Satti ML, Razzaq K, Ather NA. The Clinical Course of Typhoid Fever And Resistance Pattern of Salmonella Typhi In Patients Admitted To A Tertiary Care Hospital In Pakistan. Pak Armed Forces Med J [Internet]. 2024 Apr. 29 [cited 2024 May 24];74(2):464-8. Available from: https://pafmj.org/PAFMJ/article/view/8498

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