Pre-Eclampsia in Women with Raised C-Reactive Protein Levels Before 20th Week of Gestation; A Cohort Study


  • Komal Memon Department of Obs & Gynae, RBUT Civil Hospital, Shikarpur Pakistan
  • Shazia Jabbar Department of Obs & Gynae, Dow University of Health Sciences, Civil Hospital, Karachi Pakistan
  • Marvi Bozdar Department of Obs & Gynae, Ghulam Muhammad Mahar Medical College, Civil hospital, Sukkur Pakistan
  • Sumayya Ahmed Department of Obs & Gynae, DHQ Sanghar Hospital, Pakistan
  • Shahzadi . Department of Obs & Gynae, Rural Health Center, Hyderabad Tando Qaiser Pakistan
  • Maryam Younus Department of Bio-Statistics, Institute of Business Management, Karachi Pakistan



Body mass index, Pre-eclampsia, C-reactive protein, Pregnancy, Parity


Objective: To assess the association of pre-eclampsia in women with raised CRP before 20 weeks of gestation.

Study Design: Prospective cohort study,

Place and Duration of Study: Department of Obstetrics and Gynaecology, Civil Hospital, Karachi Pakistan, from Jan to Aug

Methodology: One hundred and sixty-eight women were included. 84 of 168 women had raised CRP, called as ExposedGroup, and 84 had normal CRP, called as Unexposed-Group. Blood samples were sent to assay serum CRP. Patients were thenfollowed up until the third trimester to observe whether women with elevated serum CRP >5 mg/l or women with normal levels of CRP developed pre-eclampsia.

Results: The average age of the women was 26.30±5.15 years. The pre-eclampsia was significantly high in the Exposed-Group as compared to the Unexposed-Group (p=0.019). The pre-eclampsia was two times more likely in the Exposed-Group as compared to the Unexposed-Group (RR=1.73; 95% CI 1.07-2.79).


Conclusion: Pre-eclampsia is more likely to occur before 20 weeks of pregnancy in women having raised CRP. Therefore,
effective monitoring of CRP could help in timely management and prevent severity.


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Author Biography

Komal Memon, Department of Obs & Gynae, RBUT Civil Hospital, Shikarpur Pakistan




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How to Cite

Memon, K., Jabbar, S., Bozdar, M., Ahmed, S., ., S., & Younus, M. (2024). Pre-Eclampsia in Women with Raised C-Reactive Protein Levels Before 20th Week of Gestation; A Cohort Study. Pakistan Armed Forces Medical Journal, 74(1), 54–58.



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