Impact of COVID-19 in Pregnant Women and Vertical Transmission in Newborns; A Case Series
DOI:
https://doi.org/10.51253/pafmj.v74i1.8192Keywords:
APGAR score, Infant, Newborn, Pregnancy outcome, Infectious disease transmission, Vertical disease transmission, InfectiousAbstract
Objective: To assess the impact of COVID-19 in pregnant women and determine the vertical transmission in newborns.
Study Design: Case series.
Place and Duration of Study: Department of Gynecology & Obstetric, Combined Military Hospital, Gujranwala Pakistan,
from Jun to Sep 2020.
Methodology: Forty consecutive pregnant women reported as COVID-19-positive cases were included. After taking clinical
and demographic details, the maternal outcome was defined regarding shortness of breath, fever, oxygen saturation and ventilator support. The fetal outcome was defined based on APGAR score, birth weight, and Neonatal Intensive Care Unit admission. For vertical transmission, the neonatal nasopharyngeal swab samples were collected after 24 hours of birth.
Result: Forty pregnant women were included in the study with the mean age of 30.05±2.8 years, and mean gestational age of
36.08±0.717 weeks. Of the included women, 67.5% underwent C-sections, and 25.0% underwent SVD. As per fetal outcome,
most of the babies 80% were normally delivered, while 5% were IUD. Out of all, three neonates were diagnosed with vertical
transmission, but none of them developed any complications.
Conclusion: Vertical transmissions of COVID-19 among neonates were observed. No critical maternal outcome in terms of
maternal severe morbidity or mortality was observed. However, further studies are required on this subject.
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References
Saadaoui M, Kumar M, Al Khodor S. COVID-19 Infection during
Pregnancy: Risk of Vertical Transmission, Fetal, and Neonatal
Outcomes. J Pers Med 2021; 11(6): 483.
https://doi.org/10.3390/jpm11060483.
Mirbeyk M, Saghazadeh A, Rezaei N. A systematic review of
pregnant women with COVID-19 and their neonates. Arch
Gynecol Obstet 2021; 304(1): 5-38.
https://doi.org/10.1007/s00404-021-06049-z.
Karimi-Zarchi M, Neamatzadeh H, Dastgheib SA, Abbasi H,
Mirjalili SR, Behforouz A, et al. Vertical Transmission of
Coronavirus Disease 19 (COVID-19) from Infected Pregnant
Mothers to Neonates: A Review. Fetal Pediatr Pathol 2020; 39(3):
-250. https://doi.org/10.1080/15513815.2020.1747120.
Duran P, Berman S, Niermeyer S, Jaenisch T, Forster T, GomezPonce de Leon R, et al. COVID-19 and newborn health:
systematic review. Rev Panam Salud Publica 2020 ; 44: e54.
https://doi.org/10.26633/RPSP.2020.54.
Ryan GA, Purandare NC, McAuliffe FM, Hod M, Purandare CN.
Clinical update on COVID-19 in pregnancy: A review article. J
Obstet Gynaecol Res 2020; 46(8): 1235-1245.
https://doi.org/10.1111/jog.14321.
Crovetto F, Crispi F, Llurba E, Figueras F, Gómez-Roig MD,
Gratacós E. Seroprevalence and presentation of SARS-CoV-2 in
pregnancy. Lancet 2020; 396(10250): 530-531.
https://doi.org/10.1016/S0140-6736(20)31714-1.
Saadaoui M, Kumar M, Al Khodor S. COVID-19 Infection during
Pregnancy: Risk of vertical transmission, fetal, and neonatal
outcomes. J Pers Med 2021; 11(6): 483.
https://doi.org/10.3390/jpm11060483.
Yu N, Li W, Kang Q, Xiong Z, Wang S, Lin X, et al. Clinical
features and obstetric and neonatal outcomes of pregnant
patients with COVID-19 in Wuhan, China: a retrospective,
single-centre, descriptive study. Lancet Infect Dis 2020; 20(5):
-564. https://doi.org/10.1016/S1473-3099(20)30176-6.
Tolu LB, Ezeh A, Feyissa GT. Vertical transmission of Severe
Acute Respiratory Syndrome Coronavirus 2: A scoping review.
PLoS One 2021; 16(4): e0250196.
https://doi.org/10.1371/journal.pone.0250196.
Yan J, Guo J, Fan C, Juan J, Yu X, Li J, et al. Coronavirus disease
in pregnant women: a report based on 116 cases. Am J
Obstet Gynecol 2020; 223(1): 111.e1-111.e14.
https://doi.org/10.1016/j.ajog.2020.04.014.
Salvatore CM, Han JY, Acker KP, Tiwari P, Jin J, Brandler M, et
al. Neonatal management and outcomes during the COVID-19
pandemic: an observation cohort study. Lancet Child Adolesc
Health 2020; 4(10): 721-727.
https://doi.org/10.1016/S2352-4642(20)30235-2.
Moreno SC, To J, Chun H, Ngai IM. Vertical Transmission of
COVID-19 to the Neonate. Infect Dis Obstet Gynecol 2020 2;
: 8460672. https://doi.org/10.1155/2020/8460672.
Yan J, Guo J, Fan C, Juan J, Yu X, Li J, et al. Coronavirus disease
in pregnant women: a report based on 116 cases. Am J
Obstet Gynecol 2020; 223(1): 111.e1-111.e14.
https://doi.org/10.1016/j.ajog.2020.04.014.
Di Mascio D, Khalil A, Saccone G, Rizzo G, Buca D, Liberati M, et
al. Outcome of coronavirus spectrum infections (SARS, MERS,
COVID-19) during pregnancy: a systematic review and metaanalysis. Am J Obstet Gynecol MFM 2020; 2(2): 100107.
https://doi.org/10.1016/j.ajogmf.2020.100107.
AbdelMassih A, Fouda R, Essam R, Negm A, Khalil D, Habib D,
et al. COVID-19 during pregnancy should we really worry from
vertical transmission or rather from fetal hypoxia and placental
insufficiency? A systematic review. Egypt Pediatric Assoc Gaz
; 69(1): 12. https://doi.org/10.1186/s43054-021-00056-0
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