Nasal High-Frequency Oscillatory Ventilation versus Nasal Intermittent Positive Pressure Ventilation In Pre-terms With Respiratory Distress Syndrome During Early Neonatal Period: A Randomized Controlled Trial

Authors

  • Rida Ali Bahria University Medical & Dental College Karachi Pakistan
  • Shahid Mahmud Combined Military Hospital/National University of Medical Science (NUMS) Rawalpindi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v73i1.8186

Keywords:

Nasal intermittent positive pressure ventilation, Nasal high-frequency oscillatory ventilation, Respiratory distress syndrome

Abstract

Objective: To determine the effectiveness of NHFOV versus NIPPV in reducing the need for invasive mechanical ventilation in preterm neonates with RDS (moderate-severe) during the first seven days of the life of neonate.

Study Design: Randomized controlled study (ACTRN: 12622000291785).

Place and Duration of Study: Neonatal Unit, PNS Shifa Hospital, Karachi Pakistan, from Jan to Aug 2021.

Methodology: Forty-eight preterm neonates, with the gestational age of 27 weeks to 34 weeks with Respiratory distress Syndrome, were randomized to NHFOV Group (n=24) and NIPPV Group (n=24). The primary outcome was the need for invasive mechanical ventilation (IMV). The secondary outcomes were the duration of hospitalization, non-invasive respiratory support, mortality, abdominal distention, pneumothorax, need for surgery for patent ductus arteriosus, spontaneous intestinal perforation, and necrotizing enterocolitis, intraventricular haemorrhage≥ Grade-3, bronchopulmonary dysplasia, retinopathy of prematurity Stage-3.

Results: There was no significant difference between NHFOV (64.7%) versus NIPPV (35.3%) groups in need of Invasive Mechanical Ventilation (p=0.13). Secondary outcomes were not significant between the two groups, air leak (p=0.31),necrotising enterocolitis (p=1.00), broncho-pulmonary dysplasia (p=0.31), retinopathy of prematurity (p=0.15).There was no intraventricular haemorrhage found between the two groups.

Conclusion: Nasal high-frequency oscillatory ventilation was less statistically significant than NIPPV in reducing the need for invasive mechanical ventilation in the initial seven days of life in neonates with Respiratory distress syndrome.

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Published

24-02-2023

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Section

Original Articles

How to Cite

1.
Ali R, Mahmud S. Nasal High-Frequency Oscillatory Ventilation versus Nasal Intermittent Positive Pressure Ventilation In Pre-terms With Respiratory Distress Syndrome During Early Neonatal Period: A Randomized Controlled Trial. Pak Armed Forces Med J [Internet]. 2023 Feb. 24 [cited 2024 Oct. 7];73(1):151-54. Available from: https://pafmj.org/PAFMJ/article/view/8186