Association of Vitamin D Deficiency and Type-2 Diabetes Mellitus in Adults


  • Anum Gul Department of Medicine, Combined Military Hospital, Peshawar/National University of Medical Sciences (NUMS) Pakistan
  • Muhammad Amir Department of Pulmonology, Combined Military Hospital, Peshawar/National University of Medical Sciences (NUMS) Pakistan
  • Abdul Rehman Arshad Department of Nephrology, Combined Military Hospital, Peshawar/National University of Medical Sciences (NUMS) Pakistan
  • Saqib Qayyum Department of Vascular Surgery, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Aamir Hamid Khan National Key Laboratory Of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, China
  • Adan Sardar Department of Dermatology, Lady Reading Hospital, MTI Peshawar Pakistan



Type-2 diabetes mellitus, Vitamin D Deficiency, Adult, Middle Aged


Objective: To find the relationship of vitamin D deficiency with type-2 diabetes mellitus in adults.

Study Design: Comparative cross-sectional study.

Place and Duration of Study: Combined Military Hospital, Peshawar Pakistan, from Oct 2020 to Mar 2021.

Methodology: Patients with type-2 Diabetes and non-diabetics were selected outdoors and indoors using consecutive
sampling techniques. Vitamin D serum levels were measured in all participants. Vitamin D serum level <10ng/ml was
considered deficient in Vitamin D. Demographic data, duration of type-2 diabetes mellitus, diet, and co-morbidities, were
recorded. Participants were separated into groups such as Group-1, which includes diabetic patients, and Group-2, which
contains control (normal/non-diabetic) patients.

Results: In the current study, 100 participants were examined. In Diabetes-Group, Vitamin D deficiency was documented in
15(30%) patients, while in the Control (normal/no-diabetics) Group, no patients were found to have Vitamin D deficiency
(p<0.001). No significant association of Vitamin D Deficiency was recorded with age (p=0103) and gender of participants in
both groups (p=0.719).

Conclusion: In adults, type-2 diabetes mellitus is associated with Vitamin D deficiency, and diabetic patients may need to be screened for Vitamin D deficiency.


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Meo SA, Zia I, Bukhari IA, Arain SA. Type-2 diabetes mellitus in

Pakistan: Current prevalence and future forecast. J Pak Med

Assoc 2016; 66(12): 1637-1642.

Nakashima A, Yokoyama K, Yokoo T, Urashima M. Role of

vitamin D in diabetes mellitus and chronic kidney disease.

World J Diabetes 2016; 7(5): 89-100.

Hussain T, Eimal Latif AH, Malik S, Raza S, Saeed T, Salman

Zahid A, et al. Vitamin D deficiency and associated risk factors in

muslim housewives of quetta, Pakistan: A Cross-Sectional Study.

Cureus 2021; 13(9): e17643.

Khazaei Z, Khazaei S. Beigrezaei S, Nasri H. Vitamin D

deficiency in healthy people and its relationship with gender and

age. J Parathyr Dis 2018; 6(1): 16-18.

Mitri J, Pittas AG. Vitamin D and diabetes. Endocrinol Metab

Clin North Am 2014; 43(1): 205-232.

Bashir F, Khan ZU, Qureshi S, Seetlani NK, Sheikh Z. Prevalence

of hypovitaminosis D in type-2 diabetes mellitus and its

relationship with glycemic control. J Liaquat Uni Med Health Sci

; 15(02): 83-89.

Iqbal K, Islam N, Mehboobali N, Asghar A, Iqbal MP.

Association of vitamin D deficiency with poor glycaemic control

in diabetic patients. J Pak Med Assoc 2016; 66(12): 1562-1565.

Shahzad A, Sahto AA, Memon AA. Type-2 diabetics; frequency

of vitamin D deficiency. Professional Med J 2017; 24(01): 31-35.

Tariq S, Majeed Z, Ghafoor MT. Association of vitamin D

deficiency and new onset type-2 diabetes mellitus. Pak J Pathol

; 27(3): 130-135.

Bruyère O, Cavalier E, Souberbielle J, Bischoff-Ferrari H,

Beaudart C, Buckinx F, et al. Effects of vitamin D in the elderly

population: current status and perspectives. Arch Public Health

; 72(1): 32.

Shahnazari B, Moghimi J, Foroutan M, Mirmohammadkhani M,

Ghorbani A. Comparison of the effect of vitamin D on

osteoporosis and osteoporotic patients with healthy individuals

referred to the Bone Density Measurement Center. Biomol

Concepts 2019; 10(1): 44-50.

Amrein K, Scherkl M, Hoffmann M, Neuwersch-Sommeregger

S, Köstenberger M, Tmava Berisha A, et al. Vitamin D deficiency

0: an update on the current status worldwide. Eur J Clin Nutr

; 74(11): 1498-1513.

Teotia SP, Teotia M. Nutritional bone disease in Indian

population. Indian J Med Res 2008; 127(3): 219-228.

Saleem S, Siddiqui A, Iqbal Z. Vitamin D Deficiency in Patients

of Type-2 Diabetes. Pak J Med Health Sci 2017;11(4): 1324-1326.

American Diabetes Association 2. Classification and diagnosis of

diabetes: standards of medical care in diabetes-2021. Diabetes

Care 2021; 44(Suppl 1): S15-S33.

Masterson Creber RM, Fleck E, Liu J, Rothenberg G, Ryan B,

Bakken S. Identifying the Complexity of Multiple Risk Factors

for Obesity Among Urban Latinas. J Immigr Minor Health 2017;

(2): 275-284.

Wennberg AM, Spira AP, Pettigrew C, Soldan A, Zipunnikov V,

Rebok GW, et al. Blood glucose levels and cortical thinning in

cognitively normal, middle-aged adults. J Neurol Sci 2016 ; 365:


Mehboob AN, Iqbal SP, Iqbal MP. High prevalence of Vitamin D

deficiency and insufficiency in a low income peri-urban

community in Karachi. J Pak Med Assoc 2015; 65(90): 946-959.

Talaei A, Mohamadi M, Adgi Z. The effect of vitamin D on

insulin resistance in patients with type-2 diabetes. Diabetol

Metab Syndr 2013; 5(1): 8.

Alkharfy KM, Al-Daghri NM, Sabico SB, Al-Othman A,

Moharram O, Alokail MS, et al. Vitamin D supplementation in

patients with diabetes mellitus type-2 on different therapeutic

regimens: a one-year prospective study. Cardiovasc Diabetol

; 12: 113.

Angellotti E, D'Alessio D, Dawson-Hughes B, Nelson J, Cohen

RM, Gastaldelli A, et al. Vitamin D Supplementation in Patients

With Type-2 Diabetes: The Vitamin D for Established Type-2

Diabetes (DDM2) Study. J Endocr Soc 2018; 2(4): 310-321.




How to Cite

Gul, A., Amir, M., Arshad, A. R., Qayyum, S., Khan, A. H., & Sardar, A. (2024). Association of Vitamin D Deficiency and Type-2 Diabetes Mellitus in Adults. Pakistan Armed Forces Medical Journal, 74(1), 45–48.



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