Comparison of Micro Needling plus Topical Insulin with Micro Needling Alone In Patients with Atrophic Acne Scars: A Split Face Study

Authors

  • Sadia Malik Department of Dermatology, Combined Military Hospital, Gujranwala/National University of Medical Sciences (NUMS) Pakistan
  • Moizza Tahir Department of Dermatology, Combined Military Hospital, Gujranwala/National University of Medical Sciences (NUMS) Pakistan
  • Quratulain Ejaz Department of Radiology, Armed forces institute of Radiology and Imaging/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Khawar Kamal Department of Dermatology, Combined Military Hospital, Gujranwala/National University of Medical Sciences (NUMS) Pakistan
  • Sameena Kausar Department of Dermatology, Combined Military Hospital, Malir/National University of Medical Sciences (NUMS) Pakistan
  • Samra Sadaf Department of Dermatology, Combined Military Hospital, Gujranwala/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v74i2.8105

Keywords:

Atrophic acne scars, Goodman and baron’s quantitative scar scale, Micro-needling, Topical insulin

Abstract

Objective: To study the efficacy of topical Insulin with microneedling compared to microneedling alone in atrophic acne scars.

Study Design: Prospective, split face, comparative study.

Place and Duration of Study: Department of Dermatology, Combined Military Hospital, Gujranwala Pakistan, from Jan to Jul 2021.

Methodology: Fifty patients with atrophic acne scars from the dermatology outpatient department were selected. The right half of the face was treated with microneedling with Dermapen, keeping the needle depth at 2 mm, along with 40 units of Insulin, while the left half was treated with microneedling alone. The sessions were repeated at monthly intervals for a total of 3 sessions. Goodman and Baron’s quantitative scar scale was assessed at the beginning and then one month after the last (3rd) session, and improvement was measured.
Results: Pre-treatment Goodman and Barons quantitative score mean on the right half was 20.44±3.54 whereas on the left half was 20.62±3.23. Post-procedure Goodman and Baron’s quantitative grading scale mean score on the right half was 9.78±2.88 while on the left half, 10.54±2.27. The improvement in mean global scores on the right and left halves was 10.66±2.11 and 10.08±1.88, respectively. The paired sample t-test showed a significant difference (p<0.001) in the scores of both the right and the left halves.

Conclusion: Microneedling alone and combined with Insulin effectively treats atrophic acne scars.

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References

Fabbrocini G, Annunziata MC, D'Arco V, De Vita V, Lodi G,

Mauriello MC, et al. Acne Scars: Pathogenesis, Classification and

Treatment. Dermatol Res Pract 2010; 2010: 893080.

https://doi.org/10.1155/2010/893080

Connolly D, Linh Vu H, Mariwalla K, Saedi N. Acne ScarringPathogenesis, Evaluation, and Treatment Options. J Clin Aesthet

Dermatol 2017; 10(9): 12-23.

Hayashi N, Miyachi Y, Kawashima M. Prevalence of scars and

“mini-scars”, and their impact on quality of life in Japanese

patients with acne. J Dermatol 2015; 42: 690-696.

https://doi.org/10.1111/1346-8138.12885

Leyden JJ. Understanding and reducing the risk for acne scarring.

Semin Cutan Med Surg 2015; 34 (5Suppl): S89-S91.

https://doi.org/10.12788/j.sder.2015.0164

Gozali MV, Zhou B. Effectove treatments of atrophic acne scars. J

Clin Aesthet Dermatol 2015; 8(5): 33-40.

Tan J, Kang S, Leyden J. Prevalence and risk factors of acne

scarring among patients consulting dermatologists in the Unites

States. J Drugs Dermatol 2017; 16:97-102.

Asif M, Kanodia S, Singh K. Combined autologous Platelet rich

plasma with microneedling versus microneedling with distilled

water in the treatment of atrophic acne scars: a concurrent split

face study. J Cosmet Dermatol 2016; 15(4): 434-443.

https://doi.org/10.1111/jocd.12207

Kargin S. The Effects of Topical Insulin Application on Wound

Healing. Eur J Gen Med 2015; 12(4): 302-306.

https://doi.org/10.15197/ejgm.01418

Pawar M, Singh M. Microneedling with autologous platelet-rich

plasma versus micro needling with topical insulin in the

treatment of post-acne atrophic scars: a simultaneous split-face

comparative study. J Am Acad Dermatol 2021; 84(3): 810-811.

https://doi.org/10.1016/j.jaad.2020.05.152

Pooja T, Gopal KV, Rao TN, Devi BG, Kumar SA. A randomized

study to evaluate the effcacy of fractional CO2laser,

microneedling and platelet rich plasma in post-acne scarring.

Indian Dermatol Online J 2020; 11(3): 349-354.

https://doi.org/10.4103/idoj.idoj_370_19.

Layton AM, Eady EA, Zouboulis CC. Acne. In: Griffths C, Barker

J, Bleiker T, Chalmers R, Creamer D, editors. Rook’s Textbook of

Dermatology. 9th Edition. Oxford: Wiley Blackwell; 2016.

Fernandes D. Minimally invasive percutaneous collagen

induction. Oral Maxillofac Surg Clin North Am 2005; 17: 51–63.

Hou A, Cohen B, Haimovic A, Elbuluk N. Microneedling: A

Comprehensive Review. Dermatol Surg 2017; 43(3): 321-339.

https://doi.org/10.1097/DSS.0000000000000924

Chawla S. Split face comparative study of microneedling with

PRP versus microneedling with vitamin C in treating atrophic

post acne scars. J Cutan Aesthet Surg 2014; 7(4): 209-212.

https://doi.org/10.4103/0974-2077.150742

Qian H, Lu Z, Ding H, Yan S, Xiang L, Gold MH. Treatment of

acne scarring with fractional CO2 laser. J Cosmet Laser Ther

; 14(4): 162-165.

https://doi.org/10.3109/14764172.2012.699679.

Ibrahim MK, Ibrahim SM, Salem AM. Skin microneedling plus

platelet-rich plasma versus skin microneedling alone in the

treatment of atrophic post acne scars: A split face comparative

study. J Dermatolog Treat 2018; 29(3): 281-286.

https://doi.org/10.1080/09546634.2017.1365111.

Lee JW, Kim BJ, Kim MN, Mun SK. The efficacy of autologous

platelet rich plasma combined with ablative carbon dioxide

fractional resurfacing for acne scars: a simultaneous split-face

trial. Dermatol Surg 2011; 37(7): 931-938.

https://doi.org/10.1111/j.1524-4725.2011.01999.x.

Hassan R. Comparison of efficacy of micro needling for the

treatment of acne scars in Asian skin with and without subcision.

J Turk Acad Dermatol 2015; 9: 159–66.

https://doi.org/10.6003/jtad.1592a2.

Sharad J. Combination of microneedling and glycolic acid peels

for the treatment of acne scars in dark skin. J Cosmet Dermatol

; 10(4): 317-323.

https://doi.org/10.1111/j.1473-2165.2011.00583.x

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Published

29-04-2024

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How to Cite

1.
Malik S, Moizza Tahir, Quratulain Ejaz, Khawar Kamal, Sameena Kausar, Samra Sadaf. Comparison of Micro Needling plus Topical Insulin with Micro Needling Alone In Patients with Atrophic Acne Scars: A Split Face Study. Pak Armed Forces Med J [Internet]. 2024 Apr. 29 [cited 2024 Nov. 28];74(2):392-6. Available from: https://pafmj.org/PAFMJ/article/view/8105