Comparison of Micro Needling plus Topical Insulin with Micro Needling Alone In Patients with Atrophic Acne Scars: A Split Face Study
DOI:
https://doi.org/10.51253/pafmj.v74i2.8105Keywords:
Atrophic acne scars, Goodman and baron’s quantitative scar scale, Micro-needling, Topical insulinAbstract
Objective: To study the efficacy of topical Insulin with microneedling compared to microneedling alone in atrophic acne scars.
Study Design: Prospective, split face, comparative study.
Place and Duration of Study: Department of Dermatology, Combined Military Hospital, Gujranwala Pakistan, from Jan to Jul 2021.
Methodology: Fifty patients with atrophic acne scars from the dermatology outpatient department were selected. The right half of the face was treated with microneedling with Dermapen, keeping the needle depth at 2 mm, along with 40 units of Insulin, while the left half was treated with microneedling alone. The sessions were repeated at monthly intervals for a total of 3 sessions. Goodman and Baron’s quantitative scar scale was assessed at the beginning and then one month after the last (3rd) session, and improvement was measured.
Results: Pre-treatment Goodman and Barons quantitative score mean on the right half was 20.44±3.54 whereas on the left half was 20.62±3.23. Post-procedure Goodman and Baron’s quantitative grading scale mean score on the right half was 9.78±2.88 while on the left half, 10.54±2.27. The improvement in mean global scores on the right and left halves was 10.66±2.11 and 10.08±1.88, respectively. The paired sample t-test showed a significant difference (p<0.001) in the scores of both the right and the left halves.
Conclusion: Microneedling alone and combined with Insulin effectively treats atrophic acne scars.
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Fabbrocini G, Annunziata MC, D'Arco V, De Vita V, Lodi G,
Mauriello MC, et al. Acne Scars: Pathogenesis, Classification and
Treatment. Dermatol Res Pract 2010; 2010: 893080.
https://doi.org/10.1155/2010/893080
Connolly D, Linh Vu H, Mariwalla K, Saedi N. Acne ScarringPathogenesis, Evaluation, and Treatment Options. J Clin Aesthet
Dermatol 2017; 10(9): 12-23.
Hayashi N, Miyachi Y, Kawashima M. Prevalence of scars and
“mini-scars”, and their impact on quality of life in Japanese
patients with acne. J Dermatol 2015; 42: 690-696.
https://doi.org/10.1111/1346-8138.12885
Leyden JJ. Understanding and reducing the risk for acne scarring.
Semin Cutan Med Surg 2015; 34 (5Suppl): S89-S91.
https://doi.org/10.12788/j.sder.2015.0164
Gozali MV, Zhou B. Effectove treatments of atrophic acne scars. J
Clin Aesthet Dermatol 2015; 8(5): 33-40.
Tan J, Kang S, Leyden J. Prevalence and risk factors of acne
scarring among patients consulting dermatologists in the Unites
States. J Drugs Dermatol 2017; 16:97-102.
Asif M, Kanodia S, Singh K. Combined autologous Platelet rich
plasma with microneedling versus microneedling with distilled
water in the treatment of atrophic acne scars: a concurrent split
face study. J Cosmet Dermatol 2016; 15(4): 434-443.
https://doi.org/10.1111/jocd.12207
Kargin S. The Effects of Topical Insulin Application on Wound
Healing. Eur J Gen Med 2015; 12(4): 302-306.
https://doi.org/10.15197/ejgm.01418
Pawar M, Singh M. Microneedling with autologous platelet-rich
plasma versus micro needling with topical insulin in the
treatment of post-acne atrophic scars: a simultaneous split-face
comparative study. J Am Acad Dermatol 2021; 84(3): 810-811.
https://doi.org/10.1016/j.jaad.2020.05.152
Pooja T, Gopal KV, Rao TN, Devi BG, Kumar SA. A randomized
study to evaluate the effcacy of fractional CO2laser,
microneedling and platelet rich plasma in post-acne scarring.
Indian Dermatol Online J 2020; 11(3): 349-354.
https://doi.org/10.4103/idoj.idoj_370_19.
Layton AM, Eady EA, Zouboulis CC. Acne. In: Griffths C, Barker
J, Bleiker T, Chalmers R, Creamer D, editors. Rook’s Textbook of
Dermatology. 9th Edition. Oxford: Wiley Blackwell; 2016.
Fernandes D. Minimally invasive percutaneous collagen
induction. Oral Maxillofac Surg Clin North Am 2005; 17: 51–63.
Hou A, Cohen B, Haimovic A, Elbuluk N. Microneedling: A
Comprehensive Review. Dermatol Surg 2017; 43(3): 321-339.
https://doi.org/10.1097/DSS.0000000000000924
Chawla S. Split face comparative study of microneedling with
PRP versus microneedling with vitamin C in treating atrophic
post acne scars. J Cutan Aesthet Surg 2014; 7(4): 209-212.
https://doi.org/10.4103/0974-2077.150742
Qian H, Lu Z, Ding H, Yan S, Xiang L, Gold MH. Treatment of
acne scarring with fractional CO2 laser. J Cosmet Laser Ther
; 14(4): 162-165.
https://doi.org/10.3109/14764172.2012.699679.
Ibrahim MK, Ibrahim SM, Salem AM. Skin microneedling plus
platelet-rich plasma versus skin microneedling alone in the
treatment of atrophic post acne scars: A split face comparative
study. J Dermatolog Treat 2018; 29(3): 281-286.
https://doi.org/10.1080/09546634.2017.1365111.
Lee JW, Kim BJ, Kim MN, Mun SK. The efficacy of autologous
platelet rich plasma combined with ablative carbon dioxide
fractional resurfacing for acne scars: a simultaneous split-face
trial. Dermatol Surg 2011; 37(7): 931-938.
https://doi.org/10.1111/j.1524-4725.2011.01999.x.
Hassan R. Comparison of efficacy of micro needling for the
treatment of acne scars in Asian skin with and without subcision.
J Turk Acad Dermatol 2015; 9: 159–66.
https://doi.org/10.6003/jtad.1592a2.
Sharad J. Combination of microneedling and glycolic acid peels
for the treatment of acne scars in dark skin. J Cosmet Dermatol
; 10(4): 317-323.
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