Correlation of Serum Gamma Glutamyl Transferase and Prostate Specific Antigen Level in Patients with Prostate Disorders

Mehreen Aftab Khan; Ayesha Hafeez; Muhammad Younas; Syeda Binte Zahra Rizvi; Waqas Hanif; Syed  Hurr

doi:10.51253/pafmj.v75i1.8094

Authors

Mehreen Aftab Khan Department of Chemical Pathology, Combined Military Hospital, Multan/National University of Medical Sciences (NUMS) Pakistan
Ayesha Hafeez Department of Chemical Pathology, Combined Military Hospital, Multan/National University of Medical Sciences (NUMS) Pakistan
Muhammad Younas Department of Chemical Pathology, Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Syeda Binte Zahra Rizvi Department of Hematology, Combined Military Hospital, Multan/National University of Medical Sciences (NUMS) Pakistan
Waqas Hanif Department of Chemical Pathology, Combined Military Hospital, Multan/National University of Medical Sciences (NUMS) Pakistan
Syed Hurr Department of Surgery, Nishtar Medical University, Multan Pakistan

DOI:

https://doi.org/10.51253/pafmj.v75i1.8094

Keywords:

Benign prostatic hyperplasia (BPH), Gamma glutamyl transferase, Prostate specific antigen, Prostate density, “American Urological Association” (AUA) score.

Abstract

Objective: To correlate gamma-glutamyl transferase, prostate-specific antigen, and prostate-specific antigen density with ultrasound findings, including prostate-specific antigen volume and density, in patients with prostate disorders and to compare differences between Gamma-GT, prostate-specific antigen levels, and density based upon “American Urological Association” score questionnaire groups.

Study Design: Cross sectional study.

Place and Duration of Study: Combined Military Hospital Multan, Pakistan, from Nov 2019 to Dec 2021.

Methodology: We measured prostate indices, including prostate-specific antigen, prostate-specific antigen volume, prostate-specific antigen size, and prostate-specific antigen density, through biochemical measurements and ultrasound examination in a patient population [(n=336) and (age 45-90 years)] randomly after several exclusions that could have affected the results of gamma-glutamyl transferase in known prostate disorders.

Results: Gamma-glutamyl Gamma-glutamyl indices showed a low correlation with prostate-specific antigen levels (p-value= 0.170), ultrasound measures of the prostate gland (p-value=0.088), and derived indices incorporating prostate-specific antigen results (p-value=0.025). PSA showed moderate to higher correlation with Alkaline phosphatase (r=0.422, p<0.001), gamma glutamyl transferase (r=0.170, p=<0.001), PSA volume (r=0.513, p=<0.001), prostate gland size (r=0.520, p=<0.001) and PSA density (r=0.754, p=<0.001). Statistical analysis for various biochemical parameters and PSA measures between groups formulated based on prostate size and the AUA score system was not statistically significant.

Conclusion: Prostate derived ultrasound measures and PSA density showed a higher correlation with PSA. Gamma glutamyl transferase may not help depict prostate gland disease.

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