Correlation of HbA1c and Lipids with Obesity in Patients with Type 2 Diabetes in Pakistani Population

Hassan Ur Rehman; Ayesha Javed; Fibhaa` Syed; Muhammad Ali Arif; Nabeel Tariq; Anas Waheed Jami

doi:10.51253/pafmj.v73i5.8051

Authors

Hassan Ur Rehman Department of Medicine, Pakistan Institute of Medical Sciences –Shaheed Zulfiqar Ali Bhutto Medical University Islamabad Pakistan
Ayesha Javed Department of Medicine, Pakistan Institute of Medical Sciences –Shaheed Zulfiqar Ali Bhutto Medical University Islamabad Pakistan
Fibhaa` Syed Department of Medicine, Pakistan Institute of Medical Sciences –Shaheed Zulfiqar Ali Bhutto Medical University Islamabad Pakistan
Muhammad Ali Arif Department of Medicine, Pakistan Institute of Medical Sciences –Shaheed Zulfiqar Ali Bhutto Medical University Islamabad Pakistan
Nabeel Tariq Department of Medicine, Pakistan Institute of Medical Sciences –Shaheed Zulfiqar Ali Bhutto Medical University Islamabad Pakistan
Anas Waheed Jami Department of Medicine, Pakistan Institute of Medical Sciences –Shaheed Zulfiqar Ali Bhutto Medical University Islamabad Pakistan

DOI:

https://doi.org/10.51253/pafmj.v73i5.8051

Keywords:

Dyslipidemia, HbA1c, Obesity, Uncontrolled diabetes

Abstract

Objective: To quantify the correlation between Glycated Haemoglobin, Serum Lipids and overweight/obese Type II patients
with diabetes.

Study Design: Cross-sectional study.

Place and Duration of Study: Department of Internal Medicine and Endocrinology/Diabetology, PIMS (FMTI), Islamabad
Pakistan, from Jul 2020 to Dec 2020.

Methodology: The study population comprised of severely overweight and obese patients of diabetes. Their laboratory
investigations for lipid profile and HbA1c levels were measured. Correlation coefficients between lipid profile, HbA1c levels
and obesity were computed.

Results: In this study, 112 patients of diabetes were included in the study. The mean age of patients was 48.2±3.4 years, and females were slightly greater (29,51.8%). The average BMI level was 31.98±3.32kg/m2. HbA1c was found to be positively correlated with total cholesterol (r= 0.702, p-value, <0.001) and BMI (r= 0.231, p-value, 0.054) and negatively correlated with HDL levels (r= -0.372, p-value, 0.005) in the study patients. HDL was also negatively correlated with BMI levels (r= -0.314, pvalue 0.01).

Conclusion: HbA1c was positively correlated with BMI and total cholesterol in patients with diabetes. Moreover, HDL
significantly negatively correlated with obesity and HbA1c