How Significant are Insulin Resistance Parameters in Subjects with Polycystic Ovarian Syndrome (PCOS)? A Cross-Sectional Study
DOI:
https://doi.org/10.51253/pafmj.v74i1.7958Keywords:
Cardiovascular Disease (CVD), Free Androgen Index (FAI), Homeostasis model assessment for insulin resistance (HOMA-IR), DihydrotestosteroneAbstract
Objective: To evaluate insulin resistance by “Homeostasis Model Assessment for Insulin Resistance (HOMA IR)” and related
cardiovascular disease risks in females with or without polycystic ovarian syndrome.
Study Design Comparative cross-sectional study.
Place and Duration of Study: Pakistan Navy Ship Hafeez Hospital, Islamabad Pakistan, from Jan 2018 to Dec 2019.
Methodology: Patients diagnosed to have polycystic ovarian syndrome (n=158) as per Rotterdam criteria were compared with non-PCOS patients (n=162) for HOMA IR and other CVD risks. Measurement of glucose, insulin, lipid parameters and HbA1c for all subjects was carried out in fasting. PCOS was diagnosed by “Rotterdam Criteria”. Free Androgen Index was measured as FAI=(Total testosterone/SHBG) x100. Differences in insulin resistance among polycystic ovarian syndrome and nonpolycystic ovarian syndrome females were measured by the non-parametric test.
Results: Our study included 158 females (49.38%) with PCOS defined as per Rotterdam criteria, while 162 subjects did not
have PCOS (50.62%). The differences between PCOS and non-PCOS were LH: 5.15±3.66 vs. 4.58±2.87 IU/L (p=0.121), FSH:
5.87±3.57 vs. 7.26±4.63 IU/L (0.003), total testosterone: 1.76±0.86 vs. 1.17±0.45 nmol/L (<0.001) and SHBG: 41.59±31.94 vs.
55.50±34.76 (p<0.001). Insulin resistance was higher in PCOS [(3.81±3.58, n=156) in comparison to non-PCOS (3.11±2.49,
n=162), p=0.091]. Both the presence of PCOS and obesity, as measured by BMI, were associated with higher HOMA-IR.
Conclusion: Insulin resistance was found to be higher in PCOS females than in non-PCOS females. BMI also contributed to
higher insulin resistance among our study population.
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