Contributing Factors of Non-Adherence to Anti-Diabetic Therapy: A Cross-Sectional   Study from Islamabad, Pakistan

Authors

  • Hina Azeez Department of Endocrinology, Federal Government Poly Clinic (Post Graduate Medical Institute), Islamabad Pakistan
  • Gohar Khan Department of Endocrinology, Federal Government Poly Clinic (Post Graduate Medical Institute), Islamabad Pakistan
  • Muhammad Awais Tahir Department of Internal Medicine, Federal Government Poly Clinic (Post Graduate Medical Institute), Islamabad Pakistan

DOI:

https://doi.org/10.51253/pafmj.v74i4.7904

Keywords:

Diabetes mellitus type 2, Medication adherence, Patient adherence

Abstract

Objective: To assess the non-adherence to anti-diabetic therapy and factors associated with non-adherence.

Study Design: Cross-sectional study.

Place and Duration of Study: Department of Endocrinology and Diabetes, Federal Government Poly Clinic Postgraduate Medical Institute, Islamabad Pakistan, from Aug to Dec 2021.

Methodology: A total of 245 patients of diabetes were enrolled in this cross-sectional study. Patients aged 18 and 90 years and belonging to either gender were included. Patients with diabetes duration of less than 3 months, having cognitive disorder or inability to answer were excluded.

Results: The mean age of patients was 50.93±10.08 years with equal gender distribution. Non-adherence was found in 117(48%) patients. Forgetfulness was found in 111(94%), unaffordability was reported 44(37.3%), careless attitudes by 41(34.7%), poor tolerability by 57(48.3%) and leaving medicine when feeling better in 41(34.7%) patients, which were all associated with non-adherence (p<0.001). Number of medicines per day (four or more) in 60(50.9%) patients was also found to be associated with non-adherence (p=0.003).

Conclusion: A high proportion of patients of diabetes were found non-adherent to anti diabetic therapy. Forgetfulness, unaffordability and careless patient attitude were factors associated with non-adherence along with increasing number of prescribed medications.

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References

World Health Organization. Diabetes. Key facts. 2020. [Internet]. Available at: https://www.who.int/news-room/factsheets/ detail/diabetes (Accessed on December 12, 2021)

Polonsky WH, Henry RR. Poor medication adherence in type 2 diabetes: recognizing the scope of the problem and its key contributors. Patient Prefer Adherence 2016; 10: 1299-307.

https://doi.org/10.2147/PPA.S106821

Adnan M, Aasim M. Prevalence of type 2 diabetes mellitus in adult population of Pakistan: a meta-analysis of prospective cross-sectional surveys. Ann Glob Health 2020; 86(1): 7.

https://doi.org/10.5334/aogh.2677

Shams N, Amjad S, Kumar N, Ahmed W, Saleem F. Drug non-adherence in type 2 diabetes mellitus; predictors and associations. J Ayub Med Coll Abbottabad 2016; 28(2): 302-307.

Araya EM, Gebrezgabiher HA, Tekulu GH, Alema NM, Getnet D, Gebru HT, et al. Medication non-adherence and associated factors among diabetic patients visiting general hospitals in the Eastern Zone of Tigrai, Northern Ethiopia. Patient Prefer Adherence 2020; 14: 2071-2083.

https://doi.org/10.2147/PPA.S276585

Aminde LN, Tindong M, Ngwasiri CA, Aminde JA, Njim T, Fondong AA, et al. Adherence to antidiabetic medication and factors associated with nonadherence among patients with type-2 diabetes mellitus in two regional hospitals in Cameroon. BMC Endocr Disord 2019; 19(1): 35.

https://doi.org/10.1186/s12902-019-0360-9

American Diabetes Association. 2. Classification and diagnosis of diabetes: standards of medical care in diabetes-2020. Diabetes Care 2020; 43(Suppl 1): S14-S31.

https://doi.org/10.2337/dc20-S002

Hugtenburg JG, Timmers L, Elders PJ, Vervloet M, van Dijk L. Definitions, variants, and causes of nonadherence with

medication: a challenge for tailored interventions. Patient Prefer Adherence 2013; 7: 675-82. https://doi.org/10.2147/PPA.S29549

Xu N, Xie S, Chen Y, Li J, Sun L. Factors influencing medication nonadherence among Chinese older adults with diabetes mellitus. Int J Environ Res Public Health 2020; 17(17): 6012.

https://doi.org/10.3390/ijerph17176012

Osterberg L, Blaschke T. Adherence to medication. N Engl J Med 2005; 353: 487-497. https://doi.org/10.1056/NEJMra050100

Marcum ZA, Sevick MA, Handler SM. Medication non-adherence: a diagnosable and treatable medical condition. JAMA 2013; 309: 2105-2106.

https://doi.org/10.1001/jama.2013.4638

Elsous A, Radwan M, Al-Sharif H, Abu Mustafa A. Medications adherence and associated factors among patients with type 2 diabetes mellitus in the Gaza Strip, Palestine. Front Endocrinol 2017; 8: 100. https://doi.org/10.3389/fendo.2017.00100

Kini V, Ho PM. Interventions to improve medication adherence: a review. JAMA 2018; 320: 2461-2473.

https://doi.org/10.1001/jama.2018.19271

Awodele O, Osuolale JA. Medication adherence in type 2 diabetes patients: study of patients in Alimosho General Hospital, Igando, Lagos, Nigeria. Afr Health Sci 2015; 15: 513-522.

https://doi.org/10.4314/ahs.v15i2.29

Mannan A, Hasan MM, Akter F, Rana MM, Chowdhury NA, Rawal LB, et al. Factors associated with low adherence to medication among patients with type 2 diabetes at different healthcare facilities in southern Bangladesh. Glob Health Action 2021; 14(1): 1891116.

https://doi.org/10.1080/16549716.2021.1891116

Bonikowska I, Szwamel K, Uchmanowicz I. Analysis of the impact of disease acceptance, demographic, and clinical variables on adherence to treatment recommendations in elderly type 2 diabetes mellitus patients. Int J Environ Res Public Health 2021; 18(16): 8658. https://doi.org/10.3390/ijerph18168658

Demoz GT, Wahdey S, Bahrey D, Kahsay H, Woldu G, Niriayo YL, et al. Predictors of poor adherence to antidiabetic therapy in patients with type 2 diabetes: a cross-sectional study insight from Ethiopia. Diabetol Metab Syndr 2020; 12: 62.

https://doi.org/10.1186/s13098-020-00576-w

Wibowo MI, Yasin NM, Kristina SA, Prabandari YS. A systematic review on self-reported questionnaires to assess medication adherence in diabetic patients. Malays J Public Health Med 2021; 21(2): 359-73.

Waari G, Mutai J, Gikunju J. Medication adherence and factors associated with poor adherence among type 2 diabetes mellitus patients on follow-up at Kenyatta National Hospital, Kenya. Pan Afr Med J 2018; 29: 82.

https://doi.org/10.11604/pamj.2018.29.82.12639

Al-Sahouri A, Merrell J, Snelgrove S. Barriers to good glycemic control levels and adherence to diabetes management plan in adults with type 2 diabetes in Jordan: a literature review. Patient Prefer Adherence 2019; 13: 675-93.

https://doi.org/10.2147/PPA.S209679

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Published

30-08-2024

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How to Cite

1.
Hina Azeez, Gohar Khan, Muhammad Awais Tahir. Contributing Factors of Non-Adherence to Anti-Diabetic Therapy: A Cross-Sectional   Study from Islamabad, Pakistan. Pak Armed Forces Med J [Internet]. 2024 Aug. 30 [cited 2024 Nov. 22];74(4):1147-51. Available from: https://pafmj.org/PAFMJ/article/view/7904