Effect of Rectal Misoprostol in Reducing Intra-Operative Blood Loss During Myomectomy - A Randomized Controlled Trial

Salma Nisar; Muhammad Awais  Qarni; Sarah  Nisar; Sadaf  Mumtaz; Ammara Iqbal  Muhammad; Qasim  Zaheer

doi:10.51253/pafmj.v75iSUPPL-2.7751

Authors

Salma Nisar Department of Obstetrician & Gynecology, CMH Kharian, Medical College Kharian/National University of Medical Sciences (NUMS) Pakistan
Muhammad Awais Qarni Department of Anesthesia, Combined Military Hospital, Jhelum/National University of Medical Sciences (NUMS) Pakistan
Sarah Nisar Department of Obstetrician & Gynecology, Sheikh Khalifa Bin Zayed Al Nahyan/Combined Military Hospital, Rawalakot/National University of Medical Sciences (NUMS) Pakistan
Sadaf Mumtaz Department of Obstetrician & Gynecology, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Ammara Iqbal Muhammad Department of Obstetrician & Gynecology, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Qasim Zaheer Department of Obstetrician & Gynecology, Sheikh Khalifa Bin Zayed Al Nahyan/Combined Military Hospital, Rawalakot/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v75iSUPPL-2.7751

Keywords:

Intraoperative Complications, Leiomyoma, Misoprostol, Uterine Myomectomy

Abstract

Objective: To determine the effect of administration of pre-operative rectal misoprostol in reducing intra-operative blood loss during abdominal myomectomy in comparison to no treatment.

Study design: Randomized controlled trial (single blind) (NCT05108597 at Clinicaltrials.gov)

Place and Duration of the Study: Obstetrics and Gynecology department, Pak Emirates Military Hospital, Rawalpindi from March 2019 to March 2020.

Methodology: A total of 200 women for elective abdominal myomectomy were randomly allocated into two groups. In the experimental group, 100 women were administered 400ug Misoprostol through the rectal route prior to surgery and 100 were in the control group, in which no drug was administered. The surgical procedural elements, the surgeon or surgeons performing the procedure and the use of antibiotics as well as anesthetic agents was standardized to remove any bias. Intraoperative blood loss was recorded by a single trained doctor and calculated using visual scale for the abdominal sponges and chest swabs/gauzes used during surgery and blood collected in suction bottle.

Results: The mean age was 30.45±4.58 years. The mean blood loss was significantly low in experimental groups as compare to control groups [523±97.3 vs. 815.9±117.93 p<0.001]

Conclusion: In conclusion, administration of rectal misoprostol appears to be effective in reducing intra-abdominal blood loss during abdominal myomectomy.

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