Role of Serum Vitamin B12 and Glutathione Peroxidase during Third Trimester of Pregnancy with Gestational Diabetes Mellitus

Authors

  • Aasia Kanwal Shalamar Medical & Dental College, Lahore Pakistan
  • Adeela Shahid Shalamar Medical & Dental College, Lahore Pakistan
  • Aisha Bashir Shalamar Medical & Dental College, Lahore Pakistan
  • Naveed Aslam Lashari Pakistan Air Force Hospital, Islamabad Pakistan

DOI:

https://doi.org/10.51253/pafmj.v73i1.7728

Keywords:

Gestational diabetes mellitus, Glutathione peroxidase, Vitamin B12, Oxidative stress

Abstract

Objective: To investigate the role and relationship of serum Vitamin B12 and Glutathione peroxidase in pregnancy with gestational diabetes mellitus (GDM).

Study Design: Comparative cross-sectional study.

Place and Duration of Study: Physiology Department, University of Health Sciences, Lahore Pakistan, from Feb 2019 to Mar 2020.

Methodology: Ninty pregnant women were recruited, fulfilling the inclusion and exclusion criteria. Women with GDM were the cases, and those without GDM were the controls. Serum Vitamin B12 and Glutathione peroxidase were measured by ELISA.

Results: Serum Vitamin B12 was significantly lower in cases compared to controls (158.98±7.38 and 357.48±42.07mg/dL, respectively, at p<0.001. Glutathione peroxidase was also significantly lower in cases compared to controls (2.68±1.13U/mL and 5.53±1.05U/mL, respectively, at p<0.001. Correlation analysis showed that Vitamin B12 and Glutathione peroxidase had a significant positive correlation in cases (p<0.001 and rho=0.76) and a non-significant correlation in controls (p=0.87 and rho=-0.024). Linear regression analysis showed that Vitamin B12 positively affects Glutathione peroxidase (β=0.13, p<0.001).Vitamin B12 and Glutathione peroxidase have a significant, negative effect on fasting blood glucose (β =-0.06, p<0.001 and β=-
3.66, p<0.001, respectively).

Conclusion: Deficient Vitamin B12 leads to reduced Glutathione levels in GDM pregnancy. A deficiency of these two predicts elevated blood sugar levels.

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Published

24-02-2023

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Section

Original Articles

How to Cite

1.
Kanwal A, Shahid A, Bashir A, Lashari NA. Role of Serum Vitamin B12 and Glutathione Peroxidase during Third Trimester of Pregnancy with Gestational Diabetes Mellitus. Pak Armed Forces Med J [Internet]. 2023 Feb. 24 [cited 2024 Oct. 7];73(1):187-90. Available from: https://pafmj.org/PAFMJ/article/view/7728