Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome

Kazi Iftikhar  Qureshi; Tariq  Mahmood; Ali  Aftab; Ahmed Mujadid  Burki; Hatim  Saifee; Reema  Iftikhar

doi:10.51253/pafmj.v75iSUPPL-6.7686

Authors

Kazi Iftikhar Qureshi Department of Anesthesia, Pakistan Navy Station Shifa Hospital, Karachi Pakistan
Tariq Mahmood Department of Anesthesia, Pakistan Navy Station Shifa Hospital, Karachi Pakistan
Ali Aftab Department of Anesthesia, Pakistan Navy Station Shifa Hospital, Karachi Pakistan
Ahmed Mujadid Burki Department of Anesthesia, Pakistan Navy Station Shifa Hospital, Karachi Pakistan
Hatim Saifee Department of Anesthesia, Aga Khan University Hospital, Karachi Pakistan
Reema Iftikhar Department of Anesthesia, National Institute of Cardiovascular Diseases, Karachi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v75iSUPPL-6.7686

Keywords:

Acute Respiratory Distress Syndrome, Cisatracurium, Mortality

Abstract

Objective: To assess the role of early neuromuscular blockade in the acute respiratory distress syndrome among patients managed in Critical Care Unit.

Study Design: Comparative Cross-sectional Study.

Setting and Duration of Study: Critical Care Unit, Pakistan Navy Station Shifa Hospital, Karachi Pakistan, from Oct 2019 to Oct 2021.

Methodology: Patients diagnosed with moderate or severe acute respiratory distress syndrome by consultant critical care physician and admitted in critical care unit were included in the study. They were randomly divided in to two groups. Group A received cisatracurium infusion for 48 hours in addition to treatment as usual while group B just received treatment as usual. Ninety days’ mortality was assessed in all the patients and use of early neuromuscular blockade along with other factors were associated with mortality among the study participants.

Results: A total of 280 patients were admitted in the intensive care unit with moderate to severe Acute respiratory distress syndrome during the study period. Out of them 200(71.4%) were male while 80(28.6%) were female. 159(56.8%) patients survived within 90 days of admission while 121(43.2%) died within those 90 days. Use of early neuromuscular blockage had no statistically significant relationship (p-value-0.848) with 90 days’ mortality in our study participants.

Conclusion: Mortality rate was more than 40% in patients suffering from moderate to severe acute respiratory distress syndrome in our data set. Use of early neuromuscular blockage did not provide any added benefit in reduction of mortality in patients studied for two years in our critical care unit.

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